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Title: | Microsatellite Instability Predicts Clinical Outcome in Radiation-Treated Endometrioid Endometrial Cancer | Authors: | Bilbao, Cristina Lara, Pedro Carlos Ramírez Moreno, Raquel Henríquez-Hernández, Luis Alberto Rodríguez Rodríguez, Germán Alejandro Falcón, Orlando León Arencibia, Laureano Perucho, Manuel Díaz Chico, Bonifacio Carlos Diaz-Chico, Juan |
UNESCO Clasification: | 320713 Oncología | Keywords: | Microsatellite instability (MSI Radiotherapy Eendometrioid endometrial carcinoma (EEC) Outcome |
Issue Date: | 2010 | Publisher: | 0360-3016 | Journal: | International Journal of Radiation Oncology Biology Physics | Abstract: | Purpose—Microsatellite instability (MSI) is the hallmark of cancer with DNA mismatch repair (MMR) deficiency and underlies 20–30% of endometrial cancer. Some in vitro studies suggest that radiation effects are modulated by the MMR system, however, little is known about the relationship between MSI and radiation response. The aim of this study was to elucidate whether MSI predicts clinical outcome in radiation treated endometrioid endometrial cancer (EEC). | URI: | http://hdl.handle.net/10553/42579 | ISSN: | 0360-3016 | DOI: | 10.1016/j.ijrobp.2009.09.035 | Source: | International Journal Of Radiation Oncology Biology Physics[ISSN 0360-3016],v. 76 (1), p. 9-13 |
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