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Title: Pulmonary carcinoma with metastasis in a long-finned pilot whale (Globicephala melas)
Authors: Suárez-Santana, Cristian M. 
Fernández Maldonado, Carolina
Díaz-Delgado, Josué 
Arbelo, Manuel 
Suárez-Bonnet, Alejandro 
Espinosa de los Monteros, A. 
Câmara, Nakita 
Sierra Pulpillo, Eva 
Fernández, Antonio 
UNESCO Clasification: 240119 Zoología marina
310907 Patología
Keywords: Cetacean
Epithelial-to-mesenchymal transition
Pilot whale
Pulmonary carcinoma
Vasculogenic mimicry
Issue Date: 2016
Journal: BMC Veterinary Research 
Abstract: Background: Lung cancer is the most commonly diagnosed neoplasm in humans, however this does not apply to other animal species. Living in an aquatic environment the respiratory system of cetaceans had to undergo unique adaptations in order to them to survive and cope with totally different respiratory pathogens and potentially carcinogens from those affecting humans. Case presentation: This article discusses not only macroscopical, histopathological and immunohistochemical features of a pulmonary carcinoma with disseminated metastases in a long-finned pilot whale (Globicephala melas), as well as the immunohistochemical analysis performed on various tissues of cetaceans belonging to the genus Globicephala. On the necropsy examination of the carcass, multiple pulmonary nodules and generalised thoracic lymphadenomegaly were noted. Histologically, a malignant epithelial neoplasia was identified in the lung, thoracic lymph nodes, and adrenal gland. Immunohistochemical analysis revealed a pulmonary carcinoma. Vasculogenic mimicry and epithelial-to-mesenchymal transition phenotype, as suggested by cytomorphological and immunohistochemical characteristics, were observed. Conclusions: A diagnosis of metastatic pulmonary carcinoma was determined, which to the author's knowledge, appears to be not previously recorded in long-finned pilot whale species. This is also the first report of vasculogenic mimicry and epithelial-to-mesenchymal transition event in a spontaneous cancer from a cetacean species.
ISSN: 1746-6148
DOI: 10.1186/s12917-016-0855-9
Source: BMC Veterinary Research [ISSN 1746-6148], v. 12 (1), Article number 229
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