Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/42538
Title: Common swine models of cardiovascular disease for research and training
Authors: Crisóstomo, Verónica
Sun, Fei
Maynar Moliner, Manuel 
Báez-Díaz, Claudia
Blanco, Virginia
Garcia-Lindo, Mónica
Usón-Gargallo, Jesús
Sánchez-Margallo, Francisco Miguel
UNESCO Clasification: 320501 Cardiología
240111 Patología animal
320990 Farmacología experimental
Keywords: Enfermedades cardiovasculares
Issue Date: 2016
Journal: Lab Animal 
Abstract: Cardiovascular diseases are a major health concern and therefore an important topic in biomedical research. Large animal models allow researchers to assess the safety and efficacy of new cardiovascular procedures in systems that resemble human anatomy; additionally, they can be used to emulate scenarios for training purposes. Among the many biomedical models that are described in published literature, it is important that researchers understand and select those that are best suited to achieve the aims of their research, that facilitate the humane care and management of their research animals and that best promote the high ethical standards required of animal research. In this resource the authors describe some common swine models that can be easily incorporated into regular practices of research and training at biomedical institutions. These models use both native and altered vascular anatomy of swine to carry out research protocols, such as testing biological reactions to implanted materials, surgically creating aneurysms using autologous tissue and inducing myocardial infarction through closed-chest procedures. Such models can also be used for training, where native and altered vascular anatomy allow medical professionals to learn and practice challenging techniques in anatomy that closely simulates human systems.
URI: http://hdl.handle.net/10553/42538
ISSN: 0093-7355
DOI: 10.1038/laban.935
Source: Lab Animal [ISSN 0093-7355], v. 45 (2), p. 67-74
Appears in Collections:Artículos
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