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Title: Bubbles quantified in vivo by ultrasound relates to amount of gas detected post-mortem in rabbits decompressed from high pressure
Authors: Bernaldo de Quiros, Yara 
Møllerløkken, Andreas
Havnes, Marianne B.
Brubakk, Alf O.
González Díaz, Oscar Manuel 
Fernández Rodríguez, Antonio Jesús 
UNESCO Clasification: 310907 Patología
Keywords: Blockage of circulation
Bubble grade
Decompression sickness
Gas bubbles
Gas emboli
Issue Date: 2016
Project: Agl2005-07947/Gan Valoración Del Estado Sanitario de Cetáceos de la Familia Ziphiidae ("Zifios") en El Archipiélago Canario 
Patologia Embolica " Gaseosa / Grasa " en Cetaceos 
Journal: Frontiers in Physiology 
Abstract: The pathophysiological mechanism of decompression sickness is not fully understood but there is evidence that it can be caused by intravascular and autochthonous bubbles. Doppler ultrasound at a given circulatory location is used to detect and quantify the presence of intravascular gas bubbles as an indicator of decompression stress. In this manuscript we studied the relationship between presence and quantity of gas bubbles by echosonography of the pulmonary artery of anesthetized, air-breathing New Zealand White rabbits that were compressed and decompressed. Mortality rate, presence, quantity, and distribution of gas bubbles elsewhere in the body was examined postmortem. We found a strong positive relationship between high ultrasound bubble grades in the pulmonary artery, sudden death, and high amount of intra and extra vascular gas bubbles widespread throughout the entire organism. In contrast, animals with lower bubble grades survived for 1 h after decompression until sacrificed, and showed no gas bubbles during dissection.
ISSN: 1664-042X
DOI: 10.3389/fphys.2016.00310
Source: Frontiers in Physiology [ISSN 1664-042X], v. 7 (310)
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