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Title: Androgen receptor gene polymorphism influence fat accumulation: a longitudinal study from adolescence to adult age
Authors: Ponce-González, Jesús Gustavo
Rodríguez-Garcia, Lorena
Losa-Reyna, J.
Guadalupe Grau, Amelia
Rodríguez-González, F. G.
Díaz Chico, Bonifacio 
Dorado, C. 
Serrano-Sanchez, J. A. 
Calbet, J. A. L. 
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Adolescent
AR CAG polymorphisms
AR GGN polymorphisms
Fat mass
Issue Date: 2016
Project: Integracion de Los Grupos de la Obesidad y El Síndrome Metabólico .... 
Journal: Scandinavian Journal of Medicine and Science in Sports 
Abstract: To determine the influence of androgen receptor CAG and GGN repeat polymorphisms on fat mass and maximal fat oxidation (MFO), CAG and GGN repeat lengths were measured in 128 young boys, from which longitudinal data were obtained in 45 of them [mean ± SD: 12.8 ± 3.6 years old at recruitment, and 27.0 ± 4.8 years old at adult age]. Subjects were grouped as CAG short (CAGS) if harboring repeat lengths ≤ 21, the rest as CAG long (CAGL); and GGN short (GGNS) if GGN repeat lengths ≤ 23, or long if > 23 (GGNL). CAGS and GGNS were associated with lower adiposity than CAGL or GGNL (P < 0.05). There was an association between the logarithm of CAG repeats polymorphism and the changes of body mass (r = 0.34, P = 0.03). At adult age, CAGS men showed lower accumulation of total body and trunk fat mass, and lower resting metabolic rate (RMR) and MFO per kg of total lean mass compared with CAGL (P < 0.05). GGNS men also showed lower percentage of body fat (P < 0.05). In summary, androgen receptor CAG and GGN repeat polymorphisms are associated with RMR, MFO, fat mass, and its regional distribution in healthy male adolescents, influencing fat accumulation from adolescence to adult age.
ISSN: 0905-7188
DOI: 10.1111/sms.12587
Source: Scandinavian Journal Of Medicine & Science In Sports[ISSN 0905-7188],v. 26 (11), p. 1313-1320
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