Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/42210
Title: Adipose-derived mesenchymal stem cells: Are they a good therapeutic strategy for osteoarthritis?
Authors: Damia, Elena
Chicharro, Deborah
Lopez, Sergio
Cuervo, Belen
Rubio, Monica
Sopena, Joaquin J.
Vilar, José Manuel 
Carrillo, Jose Maria
UNESCO Clasification: 32 Ciencias médicas
Keywords: Osteoarthritis
Mesenchymal stem cells
Regenerative medicine
Issue Date: 2018
Publisher: 1422-0067
Journal: International Journal of Molecular Sciences 
Abstract: Osteoarthritis (OA) is a major cause of disability in elderly population around the world. More than one-third of people over 65 years old shows either clinical or radiological evidence of OA. There is no effective treatment for this degenerative disease, due to the limited capacity for spontaneous cartilage regeneration. Regarding the use of regenerative therapies, it has been reported that one option to restore degenerated cartilage are adipose-derived mesenchymal stem cells (ASCs). The purpose of this review is to describe and compare the efficacy of ASCs versus other therapies in OA. Methods: Recent studies have shown that ASCs exert paracrine effects protecting against degenerative changes in chondrocytes. According to the above, we have carried out a review of the literature using a combination of osteoarthritis, stem cells, and regenerative therapies as keywords. Results: Conventional pharmacological therapies for OA treatment are considered before the surgical option, however, they do not stop the progression of the disease. Moreover, total joint replacement is not recommended for patients under 55 years, and high tibia osteotomy (HTO) is a viable solution to address lower limb malalignment with concomitant OA, but some complications have been described. In recent years, the use of mesenchymal stem cells (MSCs) as a treatment strategy for OA is increasing considerably, thanks to their capacity to improve symptoms together with joint functionality and, therefore, the patients' quality of life. Conclusions: ASC therapy has a positive effect on patients with OA, although there is limited evidence and little long-term follow-up.
URI: http://hdl.handle.net/10553/42210
ISSN: 1422-0067
DOI: 10.3390/ijms19071926
Source: International Journal of Molecular Sciences [ISSN 1422-0067], v. 19 (7)
Appears in Collections:Reseña
Thumbnail
Adobe PDF (266,97 kB)
Show full item record

SCOPUSTM   
Citations

21
checked on Feb 28, 2021

WEB OF SCIENCETM
Citations

20
checked on Feb 28, 2021

Page view(s)

31
checked on Feb 28, 2021

Download(s)

30
checked on Feb 28, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.