Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/42032
DC FieldValueLanguage
dc.contributor.authorOdden, Aneen_US
dc.contributor.authorDenwood, Matthew J.en_US
dc.contributor.authorStuen, Snorreen_US
dc.contributor.authorRobertson, Lucy J.en_US
dc.contributor.authorRuiz Reyes, Antonioen_US
dc.contributor.authorHamnes, Inger Sofieen_US
dc.contributor.authorHektoen, Lisbethen_US
dc.contributor.authorEnemark, Heidi L.en_US
dc.date.accessioned2018-10-01T12:20:39Z-
dc.date.available2018-10-01T12:20:39Z-
dc.date.issued2018en_US
dc.identifier.issn2211-3207en_US
dc.identifier.urihttp://hdl.handle.net/10553/42032-
dc.description.abstractOvine Eimeria spp. infections cause reduced welfare, increased mortality, and substantial economic losses, and anticoccidials are crucial for their control. Recent reports of toltrazuril resistance in pigs, and anecdotal reports of reduced anticoccidial efficacy in lambs, necessitate evaluation of anticoccidial efficacy. Due to the substantial lifecycle differences between nematodes and coccidia, current WAAVP methods for assessing anthelmintic efficacy are not suitable for such evaluations. Faecal samples were collected from 8 pairs of twin lambs from 36 Norwegian sheep farms 6-8 days after turnout. One twin of each pair was then treated with 20 mg/kg toltrazuril and a second faecal sample from all lambs was collected 7-11 days later. Oocyst excretion rate in all samples was determined using McMasters. Suitability of treatment timing was investigated by evaluating the increase in mean log oocyst excretion in untreated lambs. Based on comparisons between groups, a threshold of >= 0.75 (13 farms) was used to identify farms where drug efficacy could be assessed with confidence, drug efficacy on farms with increases of >= 0.5 but< 0.75 (7 farms) were evaluated with caution, and drug efficacy on farms with increases of< 0.5 (16 farms) was not estimated. Reduction in oocyst excretion between samples from treated lambs compared with controls from the 20 farms with a threshold of = 0.5 were then analysed using a generalised linear mixed model. The results were classified based on 95% CI obtained using parametric bootstrapping. Among these 20 farms, two exhibited reduced drug efficacy (upper 95% CI < 95%), 13 had good efficacy (lower 95% CI > 90%), and for 5 the results were inconclusive. This is the first evidence-based report of reduced anticoccidial efficacy in ovine Eimeria spp. Additionally, we highlight the problem of sub-optimal timing of treatment (16/36 farms), which could potentially result in incorrect conclusions being reached regarding lack of drug efficacy.en_US
dc.languageengen_US
dc.publisher2211-3207
dc.relation.ispartofInternational Journal for Parasitology: Drugs and Drug Resistanceen_US
dc.sourceInternational Journal for Parasitology: Drugs and Drug Resistance [ISSN 2211-3207], v. 8 (2), p. 304-311en_US
dc.subject3109 Ciencias veterinariasen_US
dc.subject.otherEimeria spp.en_US
dc.subject.otherAnticoccidial efficacyen_US
dc.subject.otherDrug resistanceen_US
dc.subject.otherField evaluationen_US
dc.subject.otherNorway Sheepen_US
dc.titleField evaluation of anticoccidial efficacy: A novel approach demonstrates reduced efficacy of toltrazuril against ovine Eimeria spp. in Norwayen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.ijpddr.2018.05.002
dc.identifier.scopus85047102439
dc.identifier.isi000438125200017-
dc.contributor.authorscopusid57193265897
dc.contributor.authorscopusid24767762700
dc.contributor.authorscopusid7003697130
dc.contributor.authorscopusid7201408426
dc.contributor.authorscopusid57201387360
dc.contributor.authorscopusid14424184600
dc.contributor.authorscopusid55311380700
dc.contributor.authorscopusid7004124507
dc.description.lastpage311-
dc.identifier.issue2-
dc.description.firstpage304-
dc.relation.volume8-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid7631748
dc.contributor.daisngid1376051
dc.contributor.daisngid461267
dc.contributor.daisngid151362
dc.contributor.daisngid1497623
dc.contributor.daisngid2602045
dc.contributor.daisngid2777901
dc.contributor.daisngid849207
dc.contributor.wosstandardWOS:Odden, A
dc.contributor.wosstandardWOS:Denwood, MJ
dc.contributor.wosstandardWOS:Stuen, S
dc.contributor.wosstandardWOS:Robertson, LJ
dc.contributor.wosstandardWOS:Ruiz, A
dc.contributor.wosstandardWOS:Hamnes, IS
dc.contributor.wosstandardWOS:Hektoen, L
dc.contributor.wosstandardWOS:Enemark, HL
dc.date.coverdateAgosto 2018
dc.identifier.ulpgces
dc.description.sjr1,123
dc.description.jcr2,951
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR Parasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0003-0668-5496-
crisitem.author.parentorgDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.fullNameRuiz Reyes, Antonio-
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