Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/41935
Title: Secondary metabolites from two Hispaniola Ageratina species and their cytotoxic activity
Authors: Eiroa, José Luis 
Triana, Jorge
Pérez, Francisco J. 
Castillo, Quírico A.
Brouard, Ignacio
Quintana, José 
Estevez, Francisco 
León, Francisco
UNESCO Clasification: 3207 Patología
2306 Química orgánica
Keywords: Ageratina
Ent-labdanes
Sesquiterpene lactones
Cytotoxicity
Leukemia
Issue Date: 2018
Publisher: 1054-2523
Journal: Medicinal Chemistry Research 
Abstract: Study of the aerial parts of the two species of Ageratina: A. dictyoneura and A. illita afforded four new ent-labdane diterpenoids (1-4). Two known labdanes: 2 beta,3 alpha,15-trihydroxy-ent-labd-7-ene (5), and 2 beta,3 alpha-trihydroxy-ent-labd-7-en-15-oic acid (6); two sesquiterpene lactones: 8 beta-hydroxy-beta-cyclocostunolide (7) and eupatoriopicrin (8), one benzofuran, and six flavonoids were also isolated. Their chemical structures were determined based on extensive spectroscopic study, comparison with reported data and chemical transformations. The cytotoxicity of the new ent-labdane diterpenoids 1-3, sesquiterpene lactone 7, and the flavonoid: quercetin 3,7-dimethylether were assessed against the human myeloid leukemia U-937 cell line and found that compound 7 and quercetin 3,7-dimethylether were cytotoxic against this cell line.
URI: http://hdl.handle.net/10553/41935
ISSN: 1054-2523
DOI: 10.1007/s00044-018-2192-y
Source: Medicinal Chemistry Research [ISSN 1054-2523], v. 27 (7), p. 1792-1799
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