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Title: Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial: A case-cohort study
Authors: Razquin, Cristina
Liang, Liming
Toledo, Estefanía
Clish, Clary B.
Ruiz-Canela, Miguel
Zheng, Yan
Wang, Dong D.
Corella, Dolores
Castaner, Olga
Ros, Emilio
Aros, Fernando
Gomez-Gracia, Enrique
Fiol, Miquel
Santos-Lozano, José Manuel
Guasch-Ferre, Marta 
Serra-Majem, Lluis 
Sala-Vila, Aleix
Buil-Cosiales, Pilar
Bullo, Monica
Fito, Montserrat
Portoles, Olga
Estruch, Ramon
Salas-Salvado, Jordi
Hu, Frank B.
Martinez-Gonzalez, Miguel A.
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Cardiovascular disease
Mediterranean diet
Primary prevention
Issue Date: 2018
Journal: International Journal of Cardiology 
Abstract: Background: The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. In the frame of the PREDIMED trial, our aim was to examine the associations of baseline lipidome patterns or their changes with the risk of clinical CVD events. Methods: We included 983 participants in our case-cohort study. The end-point was the incidence of major CVD during 4.8 years of median follow-up. We repeatedly measured 202 plasma known lipid metabolites at baseline and after 1-year of intervention. Principal component analysis was used to identify lipidome factors. Among the 15 identified factors, 7 were significantly associated with CVD. Considering common patterns among factors, lipids were grouped (summed) into scores. Results: After adjustment for traditional CVD risk factors, scores of baseline polyunsaturated phosphatidylcholines (PC)/lysoPC/PC-plasmalogens and polyunsaturated cholesterol esters (CE) showed inverse associations with CVD (p = 0.036 and 0.012, respectively); whereas scores of monoacylglycerols (MAGs)/diacylglycerols (DAGs) and short triacylglycerols (TAGs) showed a direct association with CVD (p = 0.026 and 0.037, respectively). Baseline phosphatidylethanolamines (PEs) and their 1-y changes tended to be associated with higher CVD risk (p = 0.066 and 0.081, respectively). We did not find a significant effect of the intervention with the Mediterranean Diet on these scores. Conclusions: Our study suggests that polyunsaturated PCs and CEs may confer protection against CVD. In contrast, MAGs, DAGs, TAGs and PEs appeared to be associated with higher CVD risk.
ISSN: 0167-5273
DOI: 10.1016/j.ijcard.2017.10.026
Source: International Journal of Cardiology [ISSN 0167-5273], v. 253, p. 126-132
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