Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/41797
DC FieldValueLanguage
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorGuasch-Ferre, Martaen_US
dc.contributor.authorToledo, Estefaniaen_US
dc.contributor.authorClish, Clary B.en_US
dc.contributor.authorRazquin, Cristinaen_US
dc.contributor.authorLiang, Limingen_US
dc.contributor.authorWang, Dong D.en_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorEstruch, Ramonen_US
dc.contributor.authorHernaez, Alvaroen_US
dc.contributor.authorYu, Edwarden_US
dc.contributor.authorGomez-Gracia, Enriqueen_US
dc.contributor.authorZheng, Yanen_US
dc.contributor.authorAros, Fernandoen_US
dc.contributor.authorRomaguera, Doraen_US
dc.contributor.authorDennis, Courtneyen_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorLapetra, Joseen_US
dc.contributor.authorSerra-Majem, Lluisen_US
dc.contributor.authorPapandreou, Christopheren_US
dc.contributor.authorPortoles, Olgaen_US
dc.contributor.authorFito, Montserraten_US
dc.contributor.authorSalas-Salvado, Jordien_US
dc.contributor.authorHu, Frank B.en_US
dc.contributor.authorMartinez-Gonzalez, Miguel A.en_US
dc.date.accessioned2018-08-31T08:36:21Z-
dc.date.available2018-08-31T08:36:21Z-
dc.date.issued2018en_US
dc.identifier.issn0012-186Xen_US
dc.identifier.urihttp://hdl.handle.net/10553/41797-
dc.description.abstractAims/hypothesis Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial. Methods We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvención con DIeta MEDiterránea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n = 273), a MedDiet+nuts (n = 324) or a control diet (n = 295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial. Results Elevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend = 0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend<0.001). Increases in BCAA score at 1 year were associated with higher type 2 diabetes risk in the control group with HR per SD = 1.61 (95% CI 1.02, 2.54), but not in the MedDiet groups (p for interaction <0.001). The MedDiet+extra-virgin olive oil significantly reduced BCAA levels after 1 year of intervention (p = 0.005 vs the control group). Conclusions/interpretation Our results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence.en_US
dc.languageengen_US
dc.relation.ispartofDiabetologia (Berlin)en_US
dc.sourceDiabetología [ISSN 0012-186X], v. 61 (7), p. 1560-1571en_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherAromatic amino acidsen_US
dc.subject.otherBranched-chain amino acidsen_US
dc.subject.otherMediterranean dieten_US
dc.subject.otherType 2 diabetesen_US
dc.titlePlasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trialen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00125-018-4611-5en_US
dc.identifier.scopus85045441217-
dc.identifier.isi000434250500008-
dc.contributor.authorscopusid6603417884-
dc.contributor.authorscopusid55110459200-
dc.contributor.authorscopusid7003562288-
dc.contributor.authorscopusid35460787900-
dc.contributor.authorscopusid13612519200-
dc.contributor.authorscopusid7202069545-
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dc.contributor.authorscopusid7003570538-
dc.contributor.authorscopusid7005989830-
dc.contributor.authorscopusid55916184000-
dc.contributor.authorscopusid56660312400-
dc.contributor.authorscopusid57202571697-
dc.contributor.authorscopusid55762827700-
dc.contributor.authorscopusid7004158382-
dc.contributor.authorscopusid8161433300-
dc.contributor.authorscopusid57130114700-
dc.contributor.authorscopusid57202569537-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid57202560799-
dc.contributor.authorscopusid36470858000-
dc.contributor.authorscopusid6603006074-
dc.contributor.authorscopusid6602891390-
dc.contributor.authorscopusid7003357665-
dc.contributor.authorscopusid36038688700-
dc.contributor.authorscopusid7004290629-
dc.description.lastpage1571en_US
dc.identifier.issue7-
dc.description.firstpage1560en_US
dc.relation.volume61en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000434250500008-
dc.contributor.daisngid31761100-
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dc.identifier.externalWOS:000434250500008-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Ruiz-Canela, M-
dc.contributor.wosstandardWOS:Guasch-Ferre, M-
dc.contributor.wosstandardWOS:Toledo, E-
dc.contributor.wosstandardWOS:Clish, CB-
dc.contributor.wosstandardWOS:Razquin, C-
dc.contributor.wosstandardWOS:Liang, LM-
dc.contributor.wosstandardWOS:Wang, DD-
dc.contributor.wosstandardWOS:Corella, D-
dc.contributor.wosstandardWOS:Estruch, R-
dc.contributor.wosstandardWOS:Hernaez, A-
dc.contributor.wosstandardWOS:Yu, E-
dc.contributor.wosstandardWOS:Gomez-Gracia, E-
dc.contributor.wosstandardWOS:Zheng, Y-
dc.contributor.wosstandardWOS:Aros, F-
dc.contributor.wosstandardWOS:Romaguera, D-
dc.contributor.wosstandardWOS:Dennis, C-
dc.contributor.wosstandardWOS:Ros, E-
dc.contributor.wosstandardWOS:Lapetra, J-
dc.contributor.wosstandardWOS:Serra-Majem, L-
dc.contributor.wosstandardWOS:Papandreou, C-
dc.contributor.wosstandardWOS:Portoles, O-
dc.contributor.wosstandardWOS:Fito, M-
dc.contributor.wosstandardWOS:Salas-Salvado, J-
dc.contributor.wosstandardWOS:Hu, FB-
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA-
dc.date.coverdateJulio 2018en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr3,0
dc.description.jcr7,113
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
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