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http://hdl.handle.net/10553/41628
Title: | Tryptase is involved in the development of early ventilator-induced pulmonary fibrosis in sepsis-induced lung injury | Authors: | Villar, Jesús Cabrera-Benítez, Nuria E. Valladares, Francisco García-Hernández, Sonia Ramos-Nuez, Ángela Martín Barrasa, José Luis Muros, Mercedes Kacmarek, Robert M. Slutsky, Arthur S. |
UNESCO Clasification: | 3109 Ciencias veterinarias 320508 Enfermedades pulmonares |
Keywords: | Lung injury Acute lung injury Acute respiratory distress syndrome Tryptase Acute respiratory distress syndrome patient |
Issue Date: | 2015 | Journal: | Critical Care | Abstract: | Most patients with sepsis and acute lung injury require mechanical ventilation to improve oxygenation and facilitate organ repair. Mast cells are important in response to infection and resolution of tissue injury. Since tryptase secreted from mast cells has been associated with tissue fibrosis, we hypothesized that tryptase would be involved in the early development of ventilator-induced pulmonary fibrosis in a clinically relevant model of sepsis-induced lung injury. | URI: | http://hdl.handle.net/10553/41628 | ISSN: | 1466-609X | DOI: | 10.1186/s13054-015-0878-9 | Source: | Critical Care [ISSN 1466-609X], v. 19 (1), p. 138 | URL: | https://api.elsevier.com/content/abstract/scopus_id/84926666978 |
Appears in Collections: | Artículos |
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