Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/41628
Title: Tryptase is involved in the development of early ventilator-induced pulmonary fibrosis in sepsis-induced lung injury
Authors: Villar, Jesús
Cabrera-Benítez, Nuria E.
Valladares, Francisco
García-Hernández, Sonia
Ramos-Nuez, Ángela
Martín Barrasa, José Luis 
Muros, Mercedes
Kacmarek, Robert M.
Slutsky, Arthur S.
UNESCO Clasification: 3109 Ciencias veterinarias
320508 Enfermedades pulmonares
Keywords: Lung injury
Acute lung injury
Acute respiratory distress syndrome
Tryptase
Acute respiratory distress syndrome patient
Issue Date: 2015
Journal: Critical Care 
Abstract: Most patients with sepsis and acute lung injury require mechanical ventilation to improve oxygenation and facilitate organ repair. Mast cells are important in response to infection and resolution of tissue injury. Since tryptase secreted from mast cells has been associated with tissue fibrosis, we hypothesized that tryptase would be involved in the early development of ventilator-induced pulmonary fibrosis in a clinically relevant model of sepsis-induced lung injury.
URI: http://hdl.handle.net/10553/41628
ISSN: 1466-609X
DOI: 10.1186/s13054-015-0878-9
Source: Critical Care [ISSN 1466-609X], v. 19 (1), p. 138
URL: https://api.elsevier.com/content/abstract/scopus_id/84926666978
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