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Title: The role of cleaning products in epidemic allergic contact dermatitis to Methylchloroisothiazolinone/Methylisothiazolinone
Authors: Marrero-Alemán, Gabriel
Saavedra Santana, Pedro 
Liuti, Federica
Hernández, Noelia
López-Jiménez, Esmeralda
Borrego, Leopoldo 
UNESCO Clasification: 320106 Dermatología
320701 Alergias
Keywords: Methylisothiazolinone
Issue Date: 2018
Journal: Dermatitis 
Abstract: Background Sensitivity to methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) has increased rapidly over recent years. This increase is mainly related to the extensive use of high concentrations of MI in cosmetic products, although a growing number of cases of occupational allergic contact dermatitis are caused by MCI/MI. Objective The aim of this study was to examine the association between the increase in MCI/MI sensitization and the work performed by the patients in our area. Methods A retrospective study was undertaken of the records of a total of 1179 patients who had undergone contact skin patch tests for MCI/MI from January 2005 to December 2015. A multivariate logistic regression analysis was performed to identify the factors independently associated with sensitivity to MCI/MI. Results A constant increase in MCI/MI sensitization was observed over the observation period. The only work associated with a significant increase in the prevalence of MCI/MI sensitization was cleaning, with 38.5% of the cleaning professionals with MCI/MI sensitization consulting for cosmetics-related dermatitis. Conclusions Occupational sensitization to MCI/MI in cleaning professionals is worryingly increasing. This, in turn, could possibly account for many cases of cosmetics-associated contact dermatitis. Our findings suggest that a review of the regulations with regard to isothiazolinone concentrations in industrial and household detergents is necessary.
ISSN: 1710-3568
DOI: 10.1097/DER.0000000000000352
Source: Dermatitis[ISSN 1710-3568],v. 29, p. 77-80
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