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Title: Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction
Authors: Garcia, Catarina
Oliveira Silva, Catarina
Monteiro, Carlos M.
Nicolai, Marisa
Viana, Ana
Andrade, Joana M.
Barasoain, Isabel
Stankovic, Tijana
Quintana, Jose 
Hernandez Gonzalez, Inmaculada 
González Robaina, Ignacio J. 
Estevez, Francisco 
Díaz-Lanza, Ana María
Reis, Catarina P.
Afonso, Carlos A. M.
Pešić, Milica
Rijo, Patricia
UNESCO Clasification: 32 Ciencias médicas
3209 Farmacología
320101 Oncología
Keywords: Cytotoxicity
Therapy, et al
Issue Date: 2018
Journal: Future Medicinal Chemistry 
Abstract: Aim: 6,7-dehydroroyleanone (DHR) is a cytotoxic abietane present in the essential oil of Plectranthus madagascariensis. Methods/results: Different extraction parameters were tested, and its extraction optimization was accomplished with a Clevenger apparatus-based hydrodistillation. After isolation, its effect on microtubules, P-glycoprotein and caspases was assessed on several cell lines and the compound was coupled with hybrid nanoparticles. The results show that DHR does not interfere with microtubule formation, but evades the resistance mechanisms of P-glycoprotein. Strong activation of caspases-3 and -9 indicates that DHR is able to induce apoptosis by triggering the intrinsic cell death pathway. Moreover, the assembly of DHR with hybrid nanoparticles was able to potentiate the effect of DHR in cancer cells. Conclusion: DHR seems to be a promising starting material with anticancer properties to further be explored.
ISSN: 1756-8919
DOI: 10.4155/fmc-2017-0239
Source: Future Medicinal Chemistry[ISSN 1756-8919],v. 10 (10), p. 1177-1189
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