Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/40323
Título: Immune reconstitution inflammatory syndrome in HIV-infected immigrants
Autores/as: Perez-Rueda, Maria
Hernandez-Cabrera, Michele 
Frances-Urmeneta, Adela
Angel-Moreno, Alfonso
Pisos Álamo, Elena 
Jaén-Sánchez, Nieves
Carranza-Rodríguez, Cristina 
Pérez-Arellano, José L. 
Clasificación UNESCO: 320505 Enfermedades infecciosas
Palabras clave: Immune reconstitution inflammatory syndrome
IRIS
Fecha de publicación: 2017
Publicación seriada: The American journal of tropical medicine and hygiene 
Resumen: Immune reconstitution inflammatory syndrome (IRIS) includes a group of potentially serious inflammatory processes that may be present in HIV-infected patients after initiating highly active antiretroviral therapy (HAART). Paradoxical IRIS is a worsening of symptoms, after an overwhelming response to a previously diagnosed opportunistic infection (OI); unmasking IRIS reveals a previously occult OI. The main objective of the study was to describe the epidemiological, clinical, and outcome data of HIV-infected immigrants, stratified according to high-or low-income countries of origin, who developed IRIS and to compare them with native-born Spanish patients. This retrospective study reviewed all patients with HIV infection admitted to the Unit of Infectious Diseases and Tropical Medicine between 1998 and 2014. IRIS was identified in 25/138 (18%) immigrant patients and 24/473 (5%) native-born Spanish patients infected with HIV. Most cases, 19/25 (76%), were of unmasking IRIS. The time elapsed between initiation of HAART and development of IRIS was significantly longer inpatients with unmasking versus paradoxical IRIS. OIs, in particular due to mycobacteria, were the most frequently involved processes. Twenty percent of patients died. The comparison of immigrant and native-born patients found significant differences for both IRIS type (higher incidence of paradoxical forms among immigrants) and for the absence of malignancies in native-born patients. No significant differences were found when the data of immigrants from low-and high-income countries were compared.
URI: http://hdl.handle.net/10553/40323
ISSN: 0002-9637
DOI: 10.4269/ajtmh.16-0773
Fuente: The American journal of tropical medicine and hygiene [ISSN 0002-9637], v. 97 (4), p. 1072-1077
Colección:Artículos
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