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Title: Therapeutic doses of plasma rich in growth factors cannot provoke cancer by means of the IGF-1 pathway or inflammation in dogs
Authors: Vilar, Jose M. 
Damiá, E.
Rubió, M.
Santana, Angelo 
Sopena, J.
Cerón Madrigal, José Joaquín
Tvarijonaviciute, Asta
Cugat, R.
Carrillo, J.M.
UNESCO Clasification: 3109 Ciencias veterinarias
120903 Análisis de datos
240401 Bioestadística
Keywords: Plasma rich in growth factors
Insulin-like growth factor 1
C-reactive protein
CRP, et al
Issue Date: 2017
Journal: Journal of Applied Animal Research 
Abstract: A potential relationship between an increased risk of cancer and increased levels of serum insulin-like growth factor-1 (IGF-1), and presence of cancer and high levels of C-reactive protein (CRP) has been previously reported. This study evaluated the influence of a single intramuscular injection of plasma rich in growth factors (PRGF) on serum concentrations of IGF-1 and CRP in dogs. Two groups of eight healthy beagles were injected with two different doses of PRGF in lumbar muscles. For each treatment, IGF-1 and CRP were analysed from blood samples obtained at baseline and the following three days post injection. No differences were found when IGF-1 and CRP were compared among times in the two protocols. Local application of PRGF at clinical doses did not cause significant changes in systemic concentrations of IGF-1 or detectable inflammation.
ISSN: 0971-2119
DOI: 10.1080/09712119.2016.1218888
Source: Journal of Applied Animal Research[ISSN 0971-2119],v. 45, p. 490-493
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