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Title: Humoral immune responses of experimentally Eimeria ninakholyakimovae-infected goat kids
Authors: Matos, L.
Muñoz Ojeda, María del Carmen 
Molina Caballero, José Manuel 
Ferrer, Otilia 
Rodríguez, Francisco 
Pérez, D.
López, Adassa María 
Martín, Sergio 
Hermosilla, C.
Taubert, A.
Ruiz Reyes, Antonio 
UNESCO Clasification: 3109 Ciencias veterinarias
Keywords: Eimeria ninakohlyakimovae
IgA, et al
Issue Date: 2017
Journal: Comparative Immunology, Microbiology and Infectious Diseases 
Abstract: Although cellular immune reactions seem to be crucial for protective immune responses in Eimeria spp. infections, there are also evidences on an active involvement of the humoral counterpart. In the present study, we have analyzed the humoral response of goat kids subjected to primary and challenge infections with Eimeria ninakholyakimovae. Specific levels of IgG and IgM in serum samples and IgA in the ileal mucus were estimated. In infected kids, significantly increased levels of IgG were observed from 3 weeks post infection onwards in addition to an enhancement of specific IgM and secretory IgA levels. A wide range of peptides of sporulated oocyst antigen (SOA) was recognized by specific IgG as determined by immunoblotting. However, no correlations were found between immunoglobulin levels and OPG counts after challenge infection. Overall, these data indicate a significant specific humoral response of E. ninakohlyakimovae-infected goat kids that does not seem to convey immunoprotection. Further studies should be addressed to clarify if the lack of correlation might be associated to the type of antigen used for the immunoenzimatic assays, the age of the animals or other factors.
ISSN: 0147-9571
DOI: 10.1016/j.cimid.2017.04.002
Source: Comparative Immunology, Microbiology and Infectious Diseases[ISSN 0147-9571],v. 51, p. 60-65
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