Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/37092
Título: Phagocytosis imprints heterogeneity in tissue-resident macrophages
Autores/as: A-Gonzalez, Noelia
Quintana, Juan A.
García-Silva, Susana
Mazariegos, Marina
González de la Aleja, Arturo
Nicolás-Ávila, José A.
Walter, Wencke
Adrover, Jose M.
Crainiciuc, Georgiana
Kuchroo, Vijay K.
Rothlin, Carla V.
Peinado, Héctor
Castrillo Viguera, Antonio Jesús 
Ricote, Mercedes
Hidalgo, Andrés
Clasificación UNESCO: 32 Ciencias médicas
Palabras clave: Activated Receptor-Gamma
Apoptotic Cells
Gene-Expression
Epithelial-Cells
Ppar-Gamma, et al.
Fecha de publicación: 2017
Publicación seriada: Journal of Experimental Medicine 
Resumen: Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and mediated by distinct repertoires of receptors, opsonins, and transcription factors in macrophages from each tissue. Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a distinct antiinflammatory profile. Phagocytic macrophages expressed CD206, displayed blunted expression of Il1b, and supported tissue homeostasis. Thus, phagocytosis is a source of macrophage heterogeneity that acts together with tissue-derived factors to preserve homeostasis.
URI: http://hdl.handle.net/10553/37092
ISSN: 0022-1007
DOI: 10.1084/jem.20161375
Fuente: Journal of Experimental Medicine [ISSN 0022-1007], v. 214 (5), p. 1281-1296
Colección:Artículos
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