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Title: Omega-3 LCPUFA supplement: a nutritional strategy to prevent maternal and neonatal oxidative stress
Authors: Kajarabille, Naroa
Hurtado, Jose A.
Peña Quintana, Luis 
Peña, Manuela
Ruiz, Josefa
Diaz-Castro, Javier
Rodríguez Santana, Yéssica
Martin-Alvarez, Estefania
Lopez-Frias, Magdalena
Soldado, Olga
Lara-Villoslada, Federico
Ochoa Herrera, Julio José
UNESCO Clasification: 32 Ciencias médicas
Keywords: Docosahexaenoic acid (DHA)
N-3 fatty acids
Infant development
Oxidative stress
Antioxidant defence
Issue Date: 2017
Journal: Maternal and Child Nutrition 
Abstract: There is controversy about fish-oil supplementation and oxidative damage. This ambiguity should be explored to elucidate its role as modulator of oxidative stress, especially during gestation and postnatal life. This is the objective of this study. One hundred ten pregnant wom en were divided in two groups: control group CT (400 mL/day of the control dairy drink); supplemented group FO (400 mL/day of the fish oil-enriched dairy drink (±400-mg EPA-DHA/day)). Different biomarkers of o xidative damage were determined in the m other’s at enrolment, at delivery and at 2.5 and 4 months postpartum and newborns at delivery and at 2.5 mon ths postpartu m. Omega-3 LC-PUFA supplementation during pregnancy and lactation decreased plasma hydroperoxides especially in newborn at delivery (P = 0.001) and 2.5 months (P = 0.006), increased supe roxide dismutase (SOD) and catalase (CAT) in mothers at delivery (P = 0.024 (SOD)) and after 2.5 months (P = 0.040 (CAT)) and in newborns at 2.5 months (P = 0.035 (SOD); P = 0.021 (CAT)). Also, supplementation increased α-tocoferol in mothers at 2.5 months (P = 0.030) and in umbilical cord artery (P = 0.039). Higher levels of CoQ10 were found in mothers at delivery (P = 0.039) as well as in umbilical cord vein (P = 0.024) and artery (P = 0.036). Our supplementation prevents the oxidative stress in the mother and neonate during the first months of postnatal life, being a potential preventive nutritional strategy to prevent functional alt erations associated with oxidative stress t hat have an important repercussion for the neonate development in the early postnatal life.
ISSN: 1740-8695
DOI: 10.1111/mcn.12300
Source: Maternal and Child Nutrition [ISSN 1740-8695], v. 13 (2), article number e12300
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