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Title: Pharmacokinetics of meloxicam after intravenous, intramuscular and oral administration of a single dose to African grey parrots (Psittacus erithacus)
Authors: Montesinos, A.
Ardiaca, M.
Gilabert, José
Bonvehí, C.
Oros, J. 
Encinas, T.
UNESCO Clasification: 3109 Ciencias veterinarias
Keywords: Nonsteroidal Antiinflammatory Drugs
Induced Arthritis
Animals, et al
Issue Date: 2017
Journal: Journal of Veterinary Pharmacology and Therapeutics 
Abstract: Meloxicam is a nonsteroidal anti-inflammatory drug commonly used in avian species. In this study, the pharmacokinetic parameters for meloxicam were determined following single intravenous (i.v.), intramuscular (i.m.) and oral (p.o.) administrations of the drug (1mg/kgb.w.) in adult African grey parrots (Psittacus erithacus; n=6). Serial plasma samples were collected and meloxicam concentrations were determined using a validated high-performance liquid chromatography assay. A noncompartmental pharmacokinetic analysis was performed. No undesirable side effects were observed during the study. After i.v. administration, the volume of distribution, clearance and elimination half-life were 90.6 +/- 4.1mL/kg, 2.18 +/- 0.25mL/h/kg and 31.4 +/- 4.6h, respectively. The peak mean +/- SD plasma concentration was 8.32 +/- 0.95g/mL at 30min after i.m. administration. Oral administration resulted in a slower absorption (t(max)=13.2 +/- 3.5h; C-max= 4.69 +/- 0.75g/mL) and a lower bioavailability (38.1 +/- 3.6%) than for i.m.(78.4 +/- 5.5%) route. At 24h, concentrations were 5.90 +/- 0.28g/mL for i.v., 4.59 +/- 0.36g/mL for i.m. and 3.21 +/- 0.34g/mL for p.o. administrations and were higher than those published for Hispaniolan Amazon parrots at 12h with predicted analgesic effects.
ISSN: 0140-7783
DOI: 10.1111/jvp.12350
Source: Journal of Veterinary Pharmacology and Therapeutics[ISSN 0140-7783],v. 40, p. 279-284
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