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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/35747
DC FieldValueLanguage
dc.contributor.authorQuintana-Espinoza, Patriciaen_US
dc.contributor.authorMartín-Acosta, Pedroen_US
dc.contributor.authorAmesty, Ángelen_US
dc.contributor.authorMartín Rodríguez, Patriciaen_US
dc.contributor.authorLorenzo-Castrillejo, Isabelen_US
dc.contributor.authorFernández Pérez, Leandro Fcoen_US
dc.contributor.authorMachín, Félixen_US
dc.contributor.authorEstévez-Braun, Anaen_US
dc.date.accessioned2018-05-08T09:43:31Z-
dc.date.available2018-05-08T09:43:31Z-
dc.date.issued2017en_US
dc.identifier.issn0968-0896en_US
dc.identifier.urihttp://hdl.handle.net/10553/35747-
dc.description.abstractA set of 5-ethynylarylnaphthalimides was synthesized by Sonogashira cross-coupling reactions and evaluated for antiproliferative and antitopoisomerase II in vitro activities. Furthermore docking studies of these molecules as DNA-intercalators were carried out and the in vivo DNA-damaging activity was also determined with the model organism Saccharomyces cerevisiae. From the obtained results three naphthalimides 6, 13 and 14 showed strong topoisomerase II inhibitory activity. These three molecules also presented good docking scores as DNA-intercalators using a self-complementary oligodeoxynucleotide d (ATGCAT)(2) as a model, and compounds 13 and 14 were among the most cytotoxic in the in vivo DNA-damaging activity.en_US
dc.languageengen_US
dc.relation"Evaluación Preclinica de Nuevas Estructuras Quimicas Diseñadas Para Inhibir la Ruta Oncogenica Jak-Stat O Como Moduladores Selectivos de Los Receptores Estrógenos"en_US
dc.relationDesarrollo Preclínico de Nuevas Estructuras Bioactivas Moduladoras de Las Actividades Oncogénicas de Stat3/5 O de Los Receptores de Estrógenosen_US
dc.relation.ispartofBioorganic and Medicinal Chemistryen_US
dc.sourceBioorganic and Medicinal Chemistry[ISSN 0968-0896],v. 25, p. 1976-1983en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherNaphthalimidesen_US
dc.subject.otherAntiproliferative activityen_US
dc.subject.otherTopoisomerase IIen_US
dc.subject.otherDNA damageen_US
dc.subject.otherSaccaromyces cereviciaeen_US
dc.title5-Ethynylarylnaphthalimides as antitumor agents: synthesis and biological evaluationen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bmc.2017.02.024en_US
dc.identifier.scopus85013192456-
dc.identifier.isi000396798900028-
dc.contributor.authorscopusid55853678300-
dc.contributor.authorscopusid57191668358-
dc.contributor.authorscopusid14024036100-
dc.contributor.authorscopusid36604772400-
dc.contributor.authorscopusid35339523900-
dc.contributor.authorscopusid6506777525-
dc.contributor.authorscopusid6602804373-
dc.contributor.authorscopusid6701825073-
dc.identifier.eissn1464-3391-
dc.description.lastpage1983en_US
dc.identifier.issue6-
dc.description.firstpage1976en_US
dc.relation.volume25en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid10377211-
dc.contributor.daisngid8232999-
dc.contributor.daisngid3211275-
dc.contributor.daisngid3922169-
dc.contributor.daisngid4720340-
dc.contributor.daisngid795544-
dc.contributor.daisngid1106759-
dc.contributor.daisngid425077-
dc.contributor.wosstandardWOS:Quintana-Espinoza, P-
dc.contributor.wosstandardWOS:Martin-Acosta, P-
dc.contributor.wosstandardWOS:Amesty, A-
dc.contributor.wosstandardWOS:Martin-Rodriguez, P-
dc.contributor.wosstandardWOS:Lorenzo-Castrillejo, I-
dc.contributor.wosstandardWOS:Fernandez-Perez, L-
dc.contributor.wosstandardWOS:Machin, F-
dc.contributor.wosstandardWOS:Estevez-Braun, A-
dc.date.coverdateEnero 2017en_US
dc.identifier.ulpgcSíes
dc.description.sjr0,871
dc.description.jcr2,881
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-2378-3242-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMartín Rodríguez, Patricia-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
crisitem.project.principalinvestigatorFernández Pérez, Leandro Francisco-
crisitem.project.principalinvestigatorFernández Pérez, Leandro Francisco-
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