Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/35738
Title: Protective effect of homovanillyl alcohol on cardiovascular disease and total mortality: virgin olive oil, wine, and catechol-methylathion
Authors: de la Torre, R.
Corella, Dolores
Castañer, O.
Martínez-González, Miguel Ángel
Salas-Salvadó, Jordi
Vila, J.
Estruch, Ramón
Sorli, José V.
Arós, Fernando
Fiol, Miquel
Ros, Emili
Serra-Majem, Lluis 
Pintó, Xavier
Gómez-Gracia, Enrique
Lapetra, José
Ruiz-Canela, Miguel
Basora, José
Asensio, E.M.
Covas, María Isabel
Fitó, Montse
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Cardiovascular
Homovanillyl alcohol
Hydroxytyrosol
Traditional Mediterranean diet
Virgin olive oil
Issue Date: 2017
Journal: The American journal of clinical nutrition 
Abstract: Background: Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Hydroxytyrosol-related foods have been shown to protect against cardiovascular disease (CVD). Objective: We investigated the associations between hydroxytyrosol and its biological metabolite, 3-O-methyl-hydroxytyrosol, also known as homovanillyl alcohol (HVAL), with CVD and total mortality. Design: We included 1851 men and women with a mean +/- SD age of 66.8 +/- 6 y at high risk of CVD from prospective cohort data. The primary endpoint was a composite of myocardial infarction, stroke, and death from cardiovascular causes; the secondary endpoint was all-cause mortality. Twenty-four-hour urinary hydroxytyrosol and HVAL and catechol-O-methyltransferase (COMT) rs4680 genotypes were measured. Results: After multivariable adjustment, all biomarkers were associated, as a continuous variable, with lower CVD risk, but only HVAL showed a strong inverse association (HR: 0.44; 95% CI: 0.25, 0.80) for the comparison between quintiles. Only HVAL, as a continuous variable, was associated with total mortality (HR: 0.81; 95% CI: 0.70, 0.95). Individuals in the highest quintile of HVAL compared with the lowest had 9.2 (95% CI: 3.5, 20.8) and 6.3 (95% CI: 2.3, 12.1) additional years of life or years free of CVD, respectively, after 65 y. Individuals with the rs4680GG genotype had the highest HVAL concentrations (P = 0.05). There was no association between COMT genotypes and events or interaction between COMT genotypes and HVAL concentrations. Conclusions: We report, for the first time to our knowledge, an independent association between high urinary HVAL concentrations and a lower risk of CVD and total mortality in elderly individuals. VOO and wine consumption and a high metabolic COMT capacity for methylation are key factors for high HVAL concentrations. The association that stems from our results reinforces the benefits of 2 key components of the Mediterranean diet (wine and VOO).
URI: http://hdl.handle.net/10553/35738
ISSN: 0002-9165
DOI: 10.3945/ajcn.116.145813
Source: American Journal of Clinical Nutrition [ISSN 0002-9165], v. 105 (6), p. 1297-1304
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