Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/35438
Title: Relationship between adherence to Dietary Approaches to Stop Hypertension (DASH) diet indices and incidence of depression during up to 8 years of follow-up
Authors: Perez-Cornago, Aurora
Sánchez-Villegas, Almudena 
Bes-Rastrollo, Maira
Gea, Alfredo
Molero, Patricio
Lahortiga, Francisca
Martínez-González, Miguel Ángel
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: DASH
Depression
Dietary patterns
SUN cohort
Mood
Issue Date: 2017
Journal: Public Health Nutrition 
Abstract: Objective: Our aim was to evaluate the relationship between adherence to different Dietary Approaches to Stop Hypertension (DASH) diet indices and the risk of depression. Design: In a prospective study we assessed 14051 participants of a dynamic (permanently ongoing recruitment) prospective cohort (the Seguimiento Universidad de Navarra (SUN) Project), initially free of depression. At baseline, a validated FFQ was used to assess adherence to four previously proposed DASH indices (Dixon, Mellen, Fung and Gunther). To define the outcome we applied two definitions of depression: a less conservative definition including only self-reported physician-diagnosed depression (410 incident cases) and a more conservative definition that required both clinical diagnosis of depression and use of antidepressants (113 incident cases). Cox regression and restricted cubic splines analyses were performed. Results: After a median follow-up period of 8 years, the multiple-adjusted model showed an inverse association with the Fung DASH score (hazard ratio (HR)=076; 95 % CI 061, 094) when we used the less conservative definition of depression, and also under the more conservative definition (HR=063; 95 % CI 041, 095). We observed a weak inverse association with the Mellen DASH score, but no statistically significant association was found for the other definitions. The restricted cubic splines analyses suggested that these associations were non-linear (U-shaped). Conclusions: Moderate adherence to the DASH diet as operationalized by Fung and Mellen was related to lower depression risk. Since these associations were non-linear, additional prospective studies are required before the results can be generalized and clinical recommendations can be given.
URI: http://hdl.handle.net/10553/35438
ISSN: 1368-9800
DOI: 10.1017/S1368980016001531
Source: Public Health Nutrition [ISSN 1368-9800], v. 20 (13), p. 2383-2392
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