Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/35416
DC FieldValueLanguage
dc.contributor.authorPérez-Suárez, Ismaelen_US
dc.contributor.authorPonce-González, Jesús Gustavoen_US
dc.contributor.authorDe la Calle-Herrero, Jaimeen_US
dc.contributor.authorLosa-Reyna, Joséen_US
dc.contributor.authorMartin-Rincon, Marcosen_US
dc.contributor.authorMorales-Alamo, Daviden_US
dc.contributor.authorSantana, Alfredoen_US
dc.contributor.authorHolmberg, Hans-Christeren_US
dc.contributor.authorCalbet, Jose A. L.en_US
dc.contributor.otherMorales-Alamo, David-
dc.contributor.otherPonce Gonzalez, Jesus Gustavo-
dc.contributor.otherCalbet, Jose A-
dc.contributor.otherMartin-Rincon, Marcos-
dc.date.accessioned2018-04-17T07:58:32Z-
dc.date.available2018-04-17T07:58:32Z-
dc.date.issued2017en_US
dc.identifier.issn8750-7587en_US
dc.identifier.urihttp://hdl.handle.net/10553/35416-
dc.description.abstractIn obesity, leptin receptors (OBR) and leptin signaling in skeletal muscle are downregulated. To determine whether OBR and leptin signaling are upregulated with a severe energy deficit, 15 overweight men were assessed before the intervention (PRE), after 4 days of caloric restriction (3.2 kcal . kg body wt(-1).day(-1)) in combination with prolonged exercise (CRE; 8 h walking + 45 min single-arm cranking/day) to induce an energy deficit of similar to 5,500 kcal/day, and following 3 days of control diet (isoenergetic) and reduced exercise (CD). During cre, the diet consisted solely of whey protein (n = 8) or sucrose (n = 7; 0.8 g . kg body wt(-1).day(-1)). Muscle biopsies were obtained from the exercised and the nonexercised deltoid muscles and from the vastus lateralis. From PRE to CRE, serum glucose, insulin, and leptin were reduced. OBR expression was augmented in all examined muscles associated with increased maximal fat oxidation. Compared with PRE, after CD, phospho-Tyr(1141)OBR, phospho-Tyr(985)OBR, JAK2, and phosphoTyr(1007/1008)JAK2 protein expression were increased in all muscles, whereas STAT3 and phospho-Tyr(705)STAT3 were increased only in the arms. The expression of protein tyrosine phosphatase 1B (PTP1B) in skeletal muscle was increased by 18 and 45\% after CRE and CD, respectively (P < 0.05). Suppressor of cytokine signaling 3 (SOCS3) tended to increase in the legs and decrease in the arm muscles (ANOVA interaction: P < 0.05). Myosin heavy chain I isoform was associated with obr protein expression (r = -0.75), phospho-Tyr(985)OBR (r = 0.88), and phospho-tyr(705)stat3/stat3 (r = 0.74). In summary, despite increased PTP1B expression, skeletal muscle OBR and signaling are upregulated by a severe energy deficit with greater response in the arm than in the legs likely due to SOCS3 upregulation in the leg muscles.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Applied Physiologyen_US
dc.sourceJournal of Applied Physiology [ISSN 8750-7587], v. 123 (5), p. 1276-1287en_US
dc.subject241118 Fisiología del movimientoen_US
dc.subject241106 Fisiología del ejercicioen_US
dc.subject.otherEnergy balance-
dc.subject.otherLeptin-
dc.subject.otherProtein tyrosine phosphatase 1B-
dc.subject.otherSTAT3-
dc.subject.otherUltraendurance-
dc.titleSevere energy deficit upregulates leptin receptors, leptin signaling, and PTP1B in human skeletal muscleen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1152/japplphysiol.00454.2017en_US
dc.identifier.pmid123-
dc.identifier.scopus85034115698-
dc.identifier.isi000416597900029-
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dc.contributor.orcid#NODATA#-
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dcterms.isPartOfJournal Of Applied Physiology-
dcterms.sourceJournal Of Applied Physiology[ISSN 8750-7587],v. 123 (5), p. 1276-1287-
dc.contributor.authorscopusid56056361100-
dc.contributor.authorscopusid25628359100-
dc.contributor.authorscopusid56056264600-
dc.contributor.authorscopusid56297981500-
dc.contributor.authorscopusid56841673800-
dc.contributor.authorscopusid35148038500-
dc.contributor.authorscopusid55617275900-
dc.contributor.authorscopusid7005720583-
dc.contributor.authorscopusid7004323423-
dc.identifier.eissn1522-1601-
dc.description.lastpage1287en_US
dc.identifier.issue5-
dc.description.firstpage1276en_US
dc.relation.volume123en_US
dc.investigacionCiencias de la Salud-
dc.type2Artículoen_US
dc.identifier.wosWOS:000416597900029-
dc.contributor.daisngid2738067-
dc.contributor.daisngid12239588-
dc.contributor.daisngid1264657-
dc.contributor.daisngid7477285-
dc.contributor.daisngid4486976-
dc.contributor.daisngid3746436-
dc.contributor.daisngid3057600-
dc.contributor.daisngid1232764-
dc.contributor.daisngid1230811-
dc.contributor.daisngid31470516-
dc.contributor.daisngid163795-
dc.contributor.daisngid90295-
dc.identifier.investigatorRIDD-2683-2009-
dc.identifier.investigatorRIDH-9500-2015-
dc.identifier.investigatorRIDH-6693-2015-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Perez-Suarez, I-
dc.contributor.wosstandardWOS:Ponce-Gonzalez, JG-
dc.contributor.wosstandardWOS:de la Calle-Herrero, J-
dc.contributor.wosstandardWOS:Losa-Reyna, J-
dc.contributor.wosstandardWOS:Martin-Rincon, M-
dc.contributor.wosstandardWOS:Morales-Alamo, D-
dc.contributor.wosstandardWOS:Santana, A-
dc.contributor.wosstandardWOS:Holmberg, HC-
dc.contributor.wosstandardWOS:Calbet, JAL-
dc.date.coverdateNoviembre 2017en_US
dc.identifier.ulpgces
dc.description.sjr1,471
dc.description.jcr3,256
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.orcid0000-0002-3685-2331-
crisitem.author.orcid0000-0001-8463-397X-
crisitem.author.orcid0000-0002-9215-6234-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMartín Rincón, Marcos-
crisitem.author.fullNameMorales Álamo, David-
crisitem.author.fullNameSantana Rodríguez, Alfredo-
crisitem.author.fullNameLópez Calbet, José Antonio-
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