Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/35416
DC Field | Value | Language |
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dc.contributor.author | Pérez-Suárez, Ismael | en_US |
dc.contributor.author | Ponce-González, Jesús Gustavo | en_US |
dc.contributor.author | De la Calle-Herrero, Jaime | en_US |
dc.contributor.author | Losa-Reyna, José | en_US |
dc.contributor.author | Martin-Rincon, Marcos | en_US |
dc.contributor.author | Morales-Alamo, David | en_US |
dc.contributor.author | Santana, Alfredo | en_US |
dc.contributor.author | Holmberg, Hans-Christer | en_US |
dc.contributor.author | Calbet, Jose A. L. | en_US |
dc.contributor.other | Morales-Alamo, David | - |
dc.contributor.other | Ponce Gonzalez, Jesus Gustavo | - |
dc.contributor.other | Calbet, Jose A | - |
dc.contributor.other | Martin-Rincon, Marcos | - |
dc.date.accessioned | 2018-04-17T07:58:32Z | - |
dc.date.available | 2018-04-17T07:58:32Z | - |
dc.date.issued | 2017 | en_US |
dc.identifier.issn | 8750-7587 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/35416 | - |
dc.description.abstract | In obesity, leptin receptors (OBR) and leptin signaling in skeletal muscle are downregulated. To determine whether OBR and leptin signaling are upregulated with a severe energy deficit, 15 overweight men were assessed before the intervention (PRE), after 4 days of caloric restriction (3.2 kcal . kg body wt(-1).day(-1)) in combination with prolonged exercise (CRE; 8 h walking + 45 min single-arm cranking/day) to induce an energy deficit of similar to 5,500 kcal/day, and following 3 days of control diet (isoenergetic) and reduced exercise (CD). During cre, the diet consisted solely of whey protein (n = 8) or sucrose (n = 7; 0.8 g . kg body wt(-1).day(-1)). Muscle biopsies were obtained from the exercised and the nonexercised deltoid muscles and from the vastus lateralis. From PRE to CRE, serum glucose, insulin, and leptin were reduced. OBR expression was augmented in all examined muscles associated with increased maximal fat oxidation. Compared with PRE, after CD, phospho-Tyr(1141)OBR, phospho-Tyr(985)OBR, JAK2, and phosphoTyr(1007/1008)JAK2 protein expression were increased in all muscles, whereas STAT3 and phospho-Tyr(705)STAT3 were increased only in the arms. The expression of protein tyrosine phosphatase 1B (PTP1B) in skeletal muscle was increased by 18 and 45\% after CRE and CD, respectively (P < 0.05). Suppressor of cytokine signaling 3 (SOCS3) tended to increase in the legs and decrease in the arm muscles (ANOVA interaction: P < 0.05). Myosin heavy chain I isoform was associated with obr protein expression (r = -0.75), phospho-Tyr(985)OBR (r = 0.88), and phospho-tyr(705)stat3/stat3 (r = 0.74). In summary, despite increased PTP1B expression, skeletal muscle OBR and signaling are upregulated by a severe energy deficit with greater response in the arm than in the legs likely due to SOCS3 upregulation in the leg muscles. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Journal of Applied Physiology | en_US |
dc.source | Journal of Applied Physiology [ISSN 8750-7587], v. 123 (5), p. 1276-1287 | en_US |
dc.subject | 241118 Fisiología del movimiento | en_US |
dc.subject | 241106 Fisiología del ejercicio | en_US |
dc.subject.other | Energy balance | - |
dc.subject.other | Leptin | - |
dc.subject.other | Protein tyrosine phosphatase 1B | - |
dc.subject.other | STAT3 | - |
dc.subject.other | Ultraendurance | - |
dc.title | Severe energy deficit upregulates leptin receptors, leptin signaling, and PTP1B in human skeletal muscle | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1152/japplphysiol.00454.2017 | en_US |
dc.identifier.pmid | 123 | - |
dc.identifier.scopus | 85034115698 | - |
dc.identifier.isi | 000416597900029 | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dcterms.isPartOf | Journal Of Applied Physiology | - |
dcterms.source | Journal Of Applied Physiology[ISSN 8750-7587],v. 123 (5), p. 1276-1287 | - |
dc.contributor.authorscopusid | 56056361100 | - |
dc.contributor.authorscopusid | 25628359100 | - |
dc.contributor.authorscopusid | 56056264600 | - |
dc.contributor.authorscopusid | 56297981500 | - |
dc.contributor.authorscopusid | 56841673800 | - |
dc.contributor.authorscopusid | 35148038500 | - |
dc.contributor.authorscopusid | 55617275900 | - |
dc.contributor.authorscopusid | 7005720583 | - |
dc.contributor.authorscopusid | 7004323423 | - |
dc.identifier.eissn | 1522-1601 | - |
dc.description.lastpage | 1287 | en_US |
dc.identifier.issue | 5 | - |
dc.description.firstpage | 1276 | en_US |
dc.relation.volume | 123 | en_US |
dc.investigacion | Ciencias de la Salud | - |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000416597900029 | - |
dc.contributor.daisngid | 2738067 | - |
dc.contributor.daisngid | 12239588 | - |
dc.contributor.daisngid | 1264657 | - |
dc.contributor.daisngid | 7477285 | - |
dc.contributor.daisngid | 4486976 | - |
dc.contributor.daisngid | 3746436 | - |
dc.contributor.daisngid | 3057600 | - |
dc.contributor.daisngid | 1232764 | - |
dc.contributor.daisngid | 1230811 | - |
dc.contributor.daisngid | 31470516 | - |
dc.contributor.daisngid | 163795 | - |
dc.contributor.daisngid | 90295 | - |
dc.identifier.investigatorRID | D-2683-2009 | - |
dc.identifier.investigatorRID | H-9500-2015 | - |
dc.identifier.investigatorRID | H-6693-2015 | - |
dc.identifier.investigatorRID | No ID | - |
dc.contributor.wosstandard | WOS:Perez-Suarez, I | - |
dc.contributor.wosstandard | WOS:Ponce-Gonzalez, JG | - |
dc.contributor.wosstandard | WOS:de la Calle-Herrero, J | - |
dc.contributor.wosstandard | WOS:Losa-Reyna, J | - |
dc.contributor.wosstandard | WOS:Martin-Rincon, M | - |
dc.contributor.wosstandard | WOS:Morales-Alamo, D | - |
dc.contributor.wosstandard | WOS:Santana, A | - |
dc.contributor.wosstandard | WOS:Holmberg, HC | - |
dc.contributor.wosstandard | WOS:Calbet, JAL | - |
dc.date.coverdate | Noviembre 2017 | en_US |
dc.identifier.ulpgc | Sí | es |
dc.description.sjr | 1,471 | |
dc.description.jcr | 3,256 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.orcid | 0000-0002-3685-2331 | - |
crisitem.author.orcid | 0000-0001-8463-397X | - |
crisitem.author.orcid | 000-0002-1075-9948 | - |
crisitem.author.orcid | 0000-0002-9215-6234 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Martín Rincón, Marcos | - |
crisitem.author.fullName | Morales Álamo, David | - |
crisitem.author.fullName | Santana Rodríguez, Alfredo | - |
crisitem.author.fullName | López Calbet, José Antonio | - |
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