Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/21767
Title: SNPs in bone-related miRNAs are associated with the osteoporotic phenotype
Authors: De-Ugarte, Laura
Caro-Molina, Enrique
Rodríguez-Sanz, María
García-Pérez, Miguel Angel
Olmos, José M.
Sosa-Henríquez, Manuel 
Pérez-Cano, Ramón
Gómez-Alonso, Carlos
Del Río, Luis
Mateo-Agudo, Jesús
Blázquez-Cabrera, José Antonio
González-Macías, Jesús
Pino-Montes, Javier del
Muñoz-Torres, Manuel
Diaz-Curiel, Manuel
Malouf, Jorge
Cano, Antonio
Pérez-Castrillon, José Luis
Nogues, Xavier
Garcia-Giralt, Natalia
Diez-Perez, Adolfo
UNESCO Clasification: 320714 Osteopatología
241007 Genética Humana
Keywords: Postmenopausal Women
Parathyroid-Hormone
Genetic-Variants
Mineral Density
Microrna Genes
Expression
Differentiation
Fractures
Cells
Identification
Issue Date: 2017
Journal: Scientific Reports 
Abstract: Biogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotypic variability. This study aims to identify single nucleotide polymorphisms (SNPs) affecting the expression levels of bone-related mature microRNAs and thus, triggering an osteoporotic phenotype. An association analysis of SNPs located in pri-miRNA sequences with bone mineral density (BMD) was performed in the OSTEOMED2 cohort (n = 2183).
URI: http://hdl.handle.net/10553/21767
ISSN: 2045-2322
DOI: 10.1038/s41598-017-00641-7
Source: Scientific Reports [ISSN 2045-2322], v. 7 (1), (516)
Rights: by-nc-nd
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