SNPs in bone-related miRNAs are associated with the osteoporotic phenotype

Título:	SNPs in bone-related miRNAs are associated with the osteoporotic phenotype
Autores/as:	De-Ugarte, Laura Caro-Molina, Enrique Rodríguez-Sanz, María García-Pérez, Miguel Angel Olmos, José M. Sosa-Henríquez, Manuel Pérez-Cano, Ramón Gómez-Alonso, Carlos Del Río, Luis Mateo-Agudo, Jesús Blázquez-Cabrera, José Antonio González-Macías, Jesús Pino-Montes, Javier del Muñoz-Torres, Manuel Diaz-Curiel, Manuel Malouf, Jorge Cano, Antonio Pérez-Castrillon, José Luis Nogues, Xavier Garcia-Giralt, Natalia Diez-Perez, Adolfo
Clasificación UNESCO:	320714 Osteopatología 241007 Genética Humana
Palabras clave:	Postmenopausal Women Parathyroid-Hormone Genetic-Variants Mineral Density Microrna Genes, et al.
Fecha de publicación:	2017
Publicación seriada:	Scientific Reports
Resumen:	Biogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotypic variability. This study aims to identify single nucleotide polymorphisms (SNPs) affecting the expression levels of bone-related mature microRNAs and thus, triggering an osteoporotic phenotype. An association analysis of SNPs located in pri-miRNA sequences with bone mineral density (BMD) was performed in the OSTEOMED2 cohort (n = 2183).
URI:	http://hdl.handle.net/10553/21767
ISSN:	2045-2322
DOI:	10.1038/s41598-017-00641-7
Fuente:	Scientific Reports [ISSN 2045-2322], v. 7 (1), (516)
Derechos:	by-nc-nd
Colección:	Artículos

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