Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/21068
Title: White blood cell counts as risk markers of developing metabolic syndrome and its components in the Predimed study
Authors: Babio, Nancy
Ibarrola-Jurado, N.
Bullo, M.
Martínez-González, Miguel Ángel
Warnberg, Julia
Salaverría, I.
Ortega-Calvo, M.
Estruch, Ramón
Serra-Majem, Lluis 
Covas, María Isabel
Sorlí, José V.
Salas-Salvadó, Jordi
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Metabolic Syndrome
White blood cell
Predimed Study
Issue Date: 2013
Journal: PLoS ONE 
Abstract: Background: The Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities that includes hyperglucemia, hypertension, dyslipidemia and central obesity, conferring an increased risk of cardiovascular disease. The white blood cell (WBC) count has been proposed as a marker for predicting cardiovascular risk. However, few prospective studies have evaluated the relationship between WBC subtypes and risk of MetS.Methods: Participants were recruited from seven PREDIMED study centers. Both a baseline cross-sectional (n = 4,377) and a prospective assessment (n = 1,637) were performed. Participants with MetS at baseline were excluded from the longitudinal analysis. The median follow-up was 3.9 years. Anthropometric measurements, blood pressure, fasting glucose, lipid profile and WBC counts were assessed at baseline and yearly during the follow-up. Participants were categorized by baseline WBC and its subtype count quartiles. Adjusted logistic regression models were fitted to assess the risk of MetS and its components.Results: Of the 4,377 participants, 62.6% had MetS at baseline. Compared to the participants in the lowest baseline sex-adjusted quartile of WBC counts, those in the upper quartile showed an increased risk of having MetS (OR, 2.47; 95% CI, 2.03-2.99; P-trend < 0.001). This association was also observed for all WBC subtypes, except for basophils. Compared to participants in the lowest quartile, those in the top quartile of leukocyte, neutrophil and lymphocyte count had an increased risk of MetS incidence. Leukocyte and neutrophil count were found to be strongly associated with the MetS components hypertriglyceridemia and low HDL-cholesterol. Likewise, lymphocyte counts were found to be associated with the incidence of the MetS components low HDL-cholesterol and high fasting glucose. An increase in the total WBC during the follow-up was also associated with an increased risk of MetS.Conclusions: Total WBC counts, and some subtypes, were positively associated with MetS as well as hypertriglyceridemia, low HDL-cholesterol and high fasting glucose, all components of MetS.
URI: http://hdl.handle.net/10553/21068
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0058354
Source: PLoS ONE [ISSN 1932-6203], v. 8(3), e58354
Rights: by-nc-nd
Appears in Collections:Artículos
Thumbnail
Adobe PDF (347,51 kB)
Show full item record

SCOPUSTM   
Citations

56
checked on May 2, 2021

WEB OF SCIENCETM
Citations

51
checked on May 2, 2021

Page view(s)

117
checked on May 9, 2021

Download(s)

133
checked on May 9, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.