Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/19148
Title: Alcohol intake, wine consumption and thedevelopment of depression: the PREDIMED study
Authors: Gea, Alfredo
Beunza, Juan J.
Estruch, Ramón
Sánchez-Villegas, Almudena 
Salas-Salvadó, Jordi
Buil-Cosiales, P.
Gómez-Gracia, Enrique
Covas, María Isabel
Corella, Dolores
Fiol, Miquel
Arós, Fernando
Lapetra, José
Lamuela-Raventós, R.M.
Warnberg, Julia
Pinto, Xavier
Serra-Majem, Lluis 
Martínez-González, Miguel Ángel
Bautista Castaño, Inmaculada 
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Wine
Alcohol
Depression
Cohort
Issue Date: 2013
Journal: BMC Medicine 
Abstract: Background: Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake.Methods: We followed-up 5,505 high-risk men and women (55 to 80 y) of the PREDIMED Trial for up to seven years. Participants were initially free of depression or a history of depression, and did not have any history of alcohol-related problems. A 137-item validated food frequency questionnaire administered by a dietician was repeated annually to assess alcohol intake. Participants were classified as incident cases of depression when they reported a new clinical diagnosis of depression, and/or initiated the use of antidepressant drugs. Cox regression analyses were fitted over 23,655 person-years.Results: Moderate alcohol intake within the range of 5 to 15 g/day was significantly associated with lower risk of incident depression (hazard ratio (HR) and 95% confidence interval (95% CI) = 0.72 (0.53 to 0.98) versus abstainers). Specifically, wine consumption in the range of two to seven drinks/week was significantly associated with lower rates of depression (HR (95% CI) = 0.68 (0.47 to 0.98)).Conclusions: Moderate consumption of wine may reduce the incidence of depression, while heavy drinkers seem to be at higher risk.
URI: http://hdl.handle.net/10553/19148
ISSN: 1741-7015
DOI: 10.1186/1741-7015-11-192
Source: BMC Medicine [EISSN 1741-7015], v. 11 (1), 192, (Agosto 2013)
Rights: by-nc-nd
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