Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/19127
Title: Dietary fat intake and the risk of depression: The SUN Project
Authors: Sánchez-Villegas, Almudena 
Verberne, Lisa
de Irala, Jokin
Ruiz-Canela, Miguel
Toledo, Estefanía
Serra-Majem, Luis 
Martínez-González, Miguel Angel
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Depression
Diet
Fat
SUN Project
Issue Date: 2011
Project: Papel de la Ingestión de Ácidos Grasos Omega-3 y de la Actividad Física en la Prevención de la Depresión 
Red Alimentación Saludable en la Prevención Primaria de Enfermedades Crónicas: la Red Predimed. (Retics 2006) 
Journal: PLoS ONE 
Abstract: Emerging evidence relates some nutritional factors to depression risk. However, there is a scarcity of longitudinal assessments on this relationship.Objective: To evaluate the association between fatty acid intake or the use of culinary fats and depression incidence in a Mediterranean population.Material and Methods: Prospective cohort study (1999-2010) of 12,059 Spanish university graduates (mean age: 37.5 years) initially free of depression with permanently open enrolment. At baseline, a 136-item validated food frequency questionnaire was used to estimate the intake of fatty acids (saturated fatty acids (SFA), polyunsaturated fatty acids (PUFA), trans unsaturated fatty acids (TFA) and monounsaturated fatty acids (MUFA) and culinary fats (olive oil, seed oils, butter and margarine) During follow-up participants were classified as incident cases of depression if they reported a new clinical diagnosis of depression by a physician and/or initiated the use of antidepressant drugs. Cox regression models were used to calculate Hazard Ratios (HR) of incident depression and their 95% confidence intervals (CI) for successive quintiles of fats.Results: During follow-up (median: 6.1 years), 657 new cases of depression were identified. Multivariable-adjusted HR (95% CI) for depression incidence across successive quintiles of TFA intake were: 1 (ref), 1.08 (0.82-1.43), 1.17 (0.88-1.53), 1.28 (0.97-1.68), 1.42 (1.09-1.84) with a significant dose-response relationship (p for trend = 0.003). Results did not substantially change after adjusting for potential lifestyle or dietary confounders, including adherence to a Mediterranean Dietary Pattern. On the other hand, an inverse and significant dose-response relationship was obtained for MUFA (p for trend = 0.05) and PUFA (p for trend = 0.03) intake.Conclusions: A detrimental relationship was found between TFA intake and depression risk, whereas weak inverse associations were found for MUFA, PUFA and olive oil. These findings suggest that cardiovascular disease and depression may share some common nutritional determinants related to subtypes of fat intake.
URI: http://hdl.handle.net/10553/19127
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0016268
Source: PLoS One [ISSN 1932-6203], v. 6 (1), e16268 (Enero 2011)
Rights: by-nc-nd
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