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http://hdl.handle.net/10553/17988
| Título: | Associations of the FTO rs9939609 and the MC4Rrs17782313 polymorphisms with type 2 diabetesare modulated by diet, being higher whenadherence to the Mediterranean diet pattern is low | Autores/as: | Ortega-Azorín, Carolina Sorlí, José V. Asensio, Eva Coltell, Oscar Martínez-González, Miguel Ángel Salas-Salvadó, Jordi Covas, María Isabel Arós, Fernando Lapetra, José Serra-Majem, Lluis Gómez-Gracia, Enrique Fiol, Miquel Sáez-Tormo, Guillermo Pinto, Xavier Muñoz, Miguel-Angel Ros, Emilio Orodvas, José M Estruch Massana, A. Corella, Dolores |
Clasificación UNESCO: | 3206 Ciencias de la nutrición | Palabras clave: | Nutrigenetics Mediterranean diet Diabetes FTO MC4R, et al. |
Fecha de publicación: | 2012 | Publicación seriada: | Cardiovascular Diabetology | Resumen: | Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet). Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet). |
URI: | http://hdl.handle.net/10553/17988 | DOI: | 10.1186/1475-2840-11-137 | Fuente: | Cardiovascular Diabetology 2012, 11:137 | Derechos: | by-nc-nd |
| Colección: | Artículos |
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