Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/17988
Title: Associations of the FTO rs9939609 and the MC4Rrs17782313 polymorphisms with type 2 diabetesare modulated by diet, being higher whenadherence to the Mediterranean diet pattern is low
Authors: Ortega-Azorín, Carolina
Sorlí, José V.
Asensio, Eva
Coltell, Oscar
Martínez-González, Miguel Ángel
Salas-Salvadó, Jordi
Covas, María Isabel
Arós, Fernando
Lapetra, José
Serra-Majem, Lluis 
Gómez-Gracia, Enrique
Fiol, Miquel
Sáez-Tormo, Guillermo
Pinto, Xavier
Muñoz, Miguel-Angel
Ros, Emilio
Orodvas, José M
Estruch Massana, A.
Corella, Dolores
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Nutrigenetics
Mediterranean diet
Diabetes
FTO
MC4R, et al
Issue Date: 2012
Journal: Cardiovascular Diabetology 
Abstract: Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet).
Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet).
URI: http://hdl.handle.net/10553/17988
DOI: 10.1186/1475-2840-11-137
Source: Cardiovascular Diabetology 2012, 11:137
Rights: by-nc-nd
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