Please use this identifier to cite or link to this item: https://accedacris.ulpgc.es/jspui/handle/10553/148995
DC FieldValueLanguage
dc.contributor.authorCosta Rodríguez, Noeliaen_US
dc.contributor.authorVera Rodríguez, Daniel Julioen_US
dc.contributor.authorFalcón Cordón, Sorayaen_US
dc.contributor.authorMorales Fuente, Beatriz Reginaen_US
dc.contributor.authorMontoya Alonso, José Albertoen_US
dc.contributor.authorMorchon García, Rodrigoen_US
dc.contributor.authorCarretón Gómez, Elenaen_US
dc.date.accessioned2025-09-29T09:35:42Z-
dc.date.available2025-09-29T09:35:42Z-
dc.date.issued2025en_US
dc.identifier.issn1756-3305en_US
dc.identifier.otherWoS-
dc.identifier.urihttps://accedacris.ulpgc.es/jspui/handle/10553/148995-
dc.description.abstractBackground Pulmonary hypertension (PH) is a frequent complication in dogs with heartworm disease caused by Dirofilaria immitis. Although echocardiography remains the main diagnostic tool, its operator- and preload-dependence may limit accuracy. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a cardiac biomarker that increases in response to ventricular wall stress and may be useful for monitoring right-sided heart disease. This study aimed to evaluate NT-proBNP concentrations in dogs with precapillary PH due to heartworm disease during adulticide treatment. Methods In total, 90 dogs diagnosed with heartworm disease were prospectively enrolled and classified according to the presence of PH based on echocardiographic criteria. NT-proBNP concentrations were measured on days 0, 30, 60, and 90 of adulticide treatment. Additional data collected included the presence/absence of microfilariae, clinical signs, parasite burden, and renal values. Dogs received adulticidal therapy following current international guidelines. Statistical analyses assessed correlations between NT-proBNP levels, epidemiological, clinical and echocardiographic classification, and treatment progression. Results Dogs with PH had significantly higher NT-proBNP concentrations at baseline compared with those without PH (2038 +/- 1671 versus 583 +/- 185 pmol/L, P < 0.001). NT-proBNP levels were also positively correlated with parasite burden (r = 0.530, P < 0.05), presence of clinical signs (r = 0.456, P < 0.05), and age (r = 0.29, P < 0.05). During treatment, a progressive decrease in NT-proBNP concentrations was observed in dogs with PH, while levels remained stable in dogs without PH. Receiver operating characteristic (ROC) analysis identified a cut-off of 1524.8 pmol/L for detecting moderate-to-severe PH (sensitivity: 99%, specificity: 87%). Conclusions NT-proBNP is a valuable noninvasive biomarker for detecting and monitoring PH in dogs with heartworm disease. Its concentrations seem to reflect parasite burden, clinical status, and echocardiographic severity, and decline progressively with adulticide therapy. Integration of NT-proBNP into diagnostic and therapeutic protocols may enhance management of heartworm-infected dogs with suspected PH.en_US
dc.languageengen_US
dc.relation.ispartofParasites and Vectorsen_US
dc.sourceParasites and Vectors[ISSN 1756-3305],v. 18 (1), (Julio 2025)en_US
dc.subject3109 Ciencias veterinariasen_US
dc.subject320712 Parasitologíaen_US
dc.subject.otherArtery Distensibility Indexen_US
dc.subject.otherNatriuretic Peptideen_US
dc.subject.otherDoppler-Echocardiographyen_US
dc.subject.otherTreatment Protocolen_US
dc.subject.otherHeartwormen_US
dc.subject.otherDiagnosisen_US
dc.subject.otherSeverityen_US
dc.subject.otherDiseaseen_US
dc.subject.otherCardiopulmonaryen_US
dc.subject.otherBiomarkersen_US
dc.subject.otherHeartwormen_US
dc.subject.otherNt-Probnpen_US
dc.subject.otherPulmonary Hypertensionen_US
dc.subject.otherHeartworm Diseaseen_US
dc.subject.otherBiomarkeren_US
dc.subject.otherAdulticide Treatmenten_US
dc.subject.otherCanine Cardiologyen_US
dc.subject.otherEchocardiographyen_US
dc.titlePulmonary hypertension and NT‑proBNP dynamics during the course of adulticide treatment in dogs naturally infected by Dirofilaria immitisen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s13071-025-06945-2en_US
dc.identifier.isi001542181900006-
dc.identifier.issue1-
dc.relation.volume18en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid2121809-
dc.contributor.daisngid64603802-
dc.contributor.daisngid54796489-
dc.contributor.daisngid80306114-
dc.contributor.daisngid961614-
dc.contributor.daisngid488279-
dc.contributor.daisngid874292-
dc.description.numberofpages9en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Costa-Rodríguez, N-
dc.contributor.wosstandardWOS:Vera-Rodríguez, DJ-
dc.contributor.wosstandardWOS:Falcón-Cordón, S-
dc.contributor.wosstandardWOS:Morales, BR-
dc.contributor.wosstandardWOS:Montoya-Alonso, JA-
dc.contributor.wosstandardWOS:Morchón, R-
dc.contributor.wosstandardWOS:Carretón, E-
dc.date.coverdateJulio 2025en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr0,967
dc.description.jcr3,0
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds10,6
item.fulltextCon texto completo-
item.grantfulltextrestricted-
crisitem.author.deptGIR IUIBS: Medicina Veterinaria e Investigación Terapéutica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Medicina Veterinaria e Investigación Terapéutica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Medicina Veterinaria e Investigación Terapéutica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Medicina Veterinaria e Investigación Terapéutica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Medicina Veterinaria e Investigación Terapéutica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR IUIBS: Medicina Veterinaria e Investigación Terapéutica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Medicina Veterinaria e Investigación Terapéutica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0003-2574-9379-
crisitem.author.orcid0009-0003-2414-3380-
crisitem.author.orcid0009-0006-1576-147X-
crisitem.author.orcid0000-0002-2683-7592-
crisitem.author.orcid0000-0003-2699-1482-
crisitem.author.orcid0000-0001-6509-910X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCosta Rodríguez, Noelia-
crisitem.author.fullNameVera Rodríguez, Daniel Julio-
crisitem.author.fullNameFalcón Cordón, Soraya-
crisitem.author.fullNameMorales Fuente, Beatriz Regina-
crisitem.author.fullNameMontoya Alonso, José Alberto-
crisitem.author.fullNameMorchon García, Rodrigo-
crisitem.author.fullNameCarretón Gómez, Elena-
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