Identificador persistente para citar o vincular este elemento: https://accedacris.ulpgc.es/handle/10553/144548
Título: Human Pharmacokinetic Profiling and Comparative Analysis of Mangiferin and Its Monosodium Derivative from Mangifera indica Extracts Using UHPLC-MS/MS with 1H NMR and MALDI-TOF Confirmation
Autores/as: Fuentes-Rios, David
Sanchez-Rodriguez, Alvaro
López Ríos,Laura 
Garcia Gonzalez, Eduardo 
Martínez Cantón, Miriam 
Galvan Alvarez,Victor 
Gallego Sellés, Ángel 
Martín Rincón, Marcos 
López Calbet, José Antonio 
Vega Morales,Tanausu 
Clasificación UNESCO: 241106 Fisiología del ejercicio
Palabras clave: Bioavailability
Liquid Chromatography
Mangiferin
Mass Spectrometry
Pharmacokinetic, et al.
Fecha de publicación: 2025
Publicación seriada: Molecules 
Resumen: Mangiferin, a glucosyl xanthone, is a plant metabolite with promising nootropic and ergogenic properties. However, its poor and inconsistent systemic bioavailability limits its therapeutic potential. Additionally, the pharmacokinetics of mangiferin from mango leaf extract formulations remain uncharacterized in humans. This study validated a UHPLC-MS/MS method and conducted a human pharmacokinetic study approved by an ethics committee. The bioavailability of mangiferin and its monosodium salt was assessed from two standardized mango leaf extracts: MLE60, standardized to 60% mangiferin but practically insoluble in water, and MLES, the water-soluble monosodium salt form, also standardized to 60%. Twelve participants (six females) received oral doses of each extract in a crossover design with a 7-day washout period. Plasma analysis showed significantly higher AUC and Cmax values with MLES than MLE60, while Tmax and T1/2 were similar. MLES demonstrated a 2.44-fold increase in AUC0–24h compared to MLE60 (p = 0.0029 **), indicating improved bioavailability. This study highlights the salification method as a simple strategy to enhance mangiferin bioavailability, enabling broader applications in beverages and other products where solubility is a limitation.
URI: https://accedacris.ulpgc.es/handle/10553/144548
ISSN: 1420-3049
DOI: 10.3390/molecules30030461
Fuente: Molecules [EISSN 1420-3049], v. 30 (3), (Febrero 2025)
Colección:Artículos
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