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Título: | Human Pharmacokinetic Profiling and Comparative Analysis of Mangiferin and Its Monosodium Derivative from Mangifera indica Extracts Using UHPLC-MS/MS with 1H NMR and MALDI-TOF Confirmation | Autores/as: | Fuentes-Rios, David Sanchez-Rodriguez, Alvaro López Ríos,Laura Garcia Gonzalez, Eduardo Martínez Cantón, Miriam Galvan Alvarez,Victor Gallego Sellés, Ángel Martín Rincón, Marcos López Calbet, José Antonio Vega Morales,Tanausu |
Clasificación UNESCO: | 241106 Fisiología del ejercicio | Palabras clave: | Bioavailability Liquid Chromatography Mangiferin Mass Spectrometry Pharmacokinetic, et al. |
Fecha de publicación: | 2025 | Publicación seriada: | Molecules | Resumen: | Mangiferin, a glucosyl xanthone, is a plant metabolite with promising nootropic and ergogenic properties. However, its poor and inconsistent systemic bioavailability limits its therapeutic potential. Additionally, the pharmacokinetics of mangiferin from mango leaf extract formulations remain uncharacterized in humans. This study validated a UHPLC-MS/MS method and conducted a human pharmacokinetic study approved by an ethics committee. The bioavailability of mangiferin and its monosodium salt was assessed from two standardized mango leaf extracts: MLE60, standardized to 60% mangiferin but practically insoluble in water, and MLES, the water-soluble monosodium salt form, also standardized to 60%. Twelve participants (six females) received oral doses of each extract in a crossover design with a 7-day washout period. Plasma analysis showed significantly higher AUC and Cmax values with MLES than MLE60, while Tmax and T1/2 were similar. MLES demonstrated a 2.44-fold increase in AUC0–24h compared to MLE60 (p = 0.0029 **), indicating improved bioavailability. This study highlights the salification method as a simple strategy to enhance mangiferin bioavailability, enabling broader applications in beverages and other products where solubility is a limitation. | URI: | https://accedacris.ulpgc.es/handle/10553/144548 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules30030461 | Fuente: | Molecules [EISSN 1420-3049], v. 30 (3), (Febrero 2025) |
Colección: | Artículos |
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