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https://accedacris.ulpgc.es/handle/10553/143346
Título: | Study of the Solvent-Free Process of Enzymatic Synthesis of Pentyl Esters in a Packed Bed Reactor (PBR) Using the Lipozyme435 Heterogeneous Biocatalyst | Autores/as: | Lorenzo Pérez,Beatriz Ortega Saavedra, Juan González Garcicuño, Álvaro Martín del Valle, Eva |
Clasificación UNESCO: | 3303 ingeniería y tecnología químicas | Palabras clave: | Immobilized Enzymes Continuous Biosynthesis Adsorptive Control Geranyl Butyrate Lipase, et al. |
Fecha de publicación: | 2025 | Publicación seriada: | Industrial & Engineering Chemistry Research | Resumen: | This article describes a solvent-free enzymatic esterification process for the production of pentyl acetate or pentyl propanoate from pentanol and the corresponding acetic or propanoic acids. Both reactions were carried out in a continuous packed bed reactor (PBR) using the immobilized lipase Lipozyme435 as the catalyst. The effect of several variables was analyzed to determine the most suitable conditions: temperature, proportion of reactants, and flow rate of the products in the reactor. High conversions of the acid substrate (above 80%) were obtained at all working temperatures for an alcohol-to-acid molar ratio of 2 and flow rates up 1 mL/ min, demonstrating the technical feasibility of the reactor configuration for this type of synthesis. However, it was observed that the enzyme lost activity due to the synergistic effect of high temperatures (>70 °C) and an equimolar alcohol-to-acid ratio, exhibiting a behavior similar to that observed when using a batch stirring reactor (BSTR). In contrast to observations in a batch stirring reactor (BSTR) under the same conditions, the synthesis process in the PBR at 70 and 80 °C with a 2:1 alcohol-to-acid molar ratio showed no signs of enzymatic deactivation. This behavior suggests that scaling up the process for continuous industrial production is more advantageous than using small-scale batch processes. The economic indicators of the biocatalytic processes calculated here also indicated that PBR reactors are preferable for large-scale production. | URI: | https://accedacris.ulpgc.es/handle/10553/143346 | ISSN: | 0888-5885 | DOI: | 10.1021/acs.iecr.5c02780 | Fuente: | Industrial and Engineering Chemistry Research[ISSN 0888-5885],v. 64 (31), p. 15311-15319, (Julio 2025) |
Colección: | Artículos |
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