Identificador persistente para citar o vincular este elemento: https://accedacris.ulpgc.es/handle/10553/140303
Título: Adherence to the Mediterranean diet to prevent or delay hepatic steatosis: a longitudinal analysis within the PREDIMED study
Autores/as: Cueto-Galan, Raquel
Fontalba-Navas, Andres
Gutierrez-Bedmar, Mario
Ruiz-Canela, Miguel
Martinez-Gonzalez, Miguel A.
Alves, Lilian
Babio, Nancy
Fito, Montserrat
Ros, Emilio
Fiol, Miquel
Estruch, Ramon
Aros, Fernando
Serra Majem, Luis 
Pinto, Xavier
Munoz-Bravo, Carlos
Garcia-Rodriguez, Antonio
Gomez-Gracia, Enrique
Clasificación UNESCO: 32 Ciencias médicas
3206 Ciencias de la nutrición
320502 Endocrinología
Palabras clave: Fatty Liver-Disease
Physical-Activity Questionnaire
Life-Style
Metabolic Syndrome
Follow-Up, et al.
Fecha de publicación: 2025
Publicación seriada: Frontiers In Nutrition 
Resumen: Background: Little is known about the potential preventive effect of adherence to the Mediterranean diet (MedDiet) on the development of metabolic dysfunction-associated steatotic liver disease (MASLD).Aim :This study aims to determine the impact of adherence to the MedDiet on the progression of MASLD, measured using the hepatic steatosis index (HSI) at baseline and annually over a 5-year follow-up period within the framework of the PREvenci & oacute;n con DIeta MEDiterr & aacute;nea (PREDIMED) study.Method Participants from the PREDIMED trial with sufficient available data (n = 3,145) were examined annually over 5 years. Adherence to the MedDiet was evaluated using the Mediterranean Diet Adherence Screener (MEDAS) questionnaire, and the presence/severity of hepatic steatosis was determined according to the HSI. Linear mixed models were used to analyze the association between the study variables and HSI.Results The participants (57% female, 43% male) had a mean age of 67.2 (SD 6.2) years. Among the cardiovascular risk factors considered, the mean BMI was 29.81 (SD 3.62); 47% of participants had type 2 diabetes, 70% had hypercholesterolaemia, and 84% had hypertension. Over the 5-year follow-up, average adherence to the MedDiet and physical activity generally increased, while alcohol consumption, calorie intake, tobacco use, hypercholesterolaemia, and hypertension decreased. The fully adjusted multivariate model reflected a statistically significant decrease in the HSI per unit increase in adherence to the MedDiet (beta = -0.075; 95% CI: -0.128, -0.021).Conclusion: In individuals at high cardiovascular risk, adherence to the MedDiet is significantly associated with improvements in HSI. These longitudinal findings highlight the important role of the MedDiet in delaying or slowing the natural progression of MASLD, contributing to both its prevention and clinical management.
URI: https://accedacris.ulpgc.es/handle/10553/140303
ISSN: 2296-861X
DOI: 10.3389/fnut.2025.1518082
Fuente: Frontiers In Nutrition [ISSN 2296-861X], v. 12, (Mayo 2025)
Colección:Artículos
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