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http://hdl.handle.net/10553/135722
Título: | Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study | Autores/as: | Clavo, Bernardino Rodríguez-Abreu, Delvys Galván-Ruiz, Saray Federico, Mario Cánovas-Molina, Angeles Ramallo-Fariña, Yolanda Antonilli, Carla Benítez, Gretel Fabelo, Himar García-Lourve, Carla González-Beltrán, Damián Jorge, Ignacio J. Rodríguez-Esparragon, Francisco Callicó, Gustavo M. |
Clasificación UNESCO: | 3314 Tecnología médica | Palabras clave: | Cancer Survivors Chemotherapy-Induced Peripheral Neuropathy Grade Of Toxicity Nrf2 Numbness And Tingling, et al. |
Fecha de publicación: | 2025 | Publicación seriada: | Integrative Cancer Therapies | Resumen: | Background: Numbness and tingling secondary to chemotherapy-induced peripheral neuropathy (CIPN) are frequent side effects that limit chemotherapy treatment and quality of life. Successful treatments for CIPN are limited. This preliminary report shows the potential long-term effects of ozone treatment in the management of persistent numbness and tingling secondary to CIPN. Methods: Ozone treatment was administered by rectal insufflation in 15 patients (female/male: 8/7, age: 66 years old) suffering from persistent numbness and tingling secondary to grade-2 or grade-3 CIPN. Planned ozone treatment consisted of 40 sessions over 4 months. The initial concentration of 10 μg/mL was progressively increased to 30 μg/mL. The initial gas volume of 180 mL/session was progressively increased to 300 mL/session if tolerated. Before and after ozone treatment, and at 3- and 6- months after the end of treatment, they were assessed (i) the grade of CIPN-toxicity, and (ii) the self-reported decrease in numbness and tingling. Results: After ozone treatment, 47% of patients experienced a decrease in the grade of CIPN-toxicity (P =.016), and 67% of patients reported a decrease in numbness and tingling ≥50% (P =.002). These effects were maintained at 3- and 6- months after the end of O3T. Conclusions: In this retrospective report, patients with persistent numbness and tingling secondary to CIPN showed clinically relevant and long-term improvements after ozone treatment. The magnitude and duration of the observed effects merit further research and support our ongoing clinical trials. | URI: | http://hdl.handle.net/10553/135722 | ISSN: | 1534-7354 | DOI: | 10.1177/15347354241307038 | Fuente: | Integrative Cancer Therapies[ISSN 1534-7354],v. 24, (Enero 2025) |
Colección: | Artículos |
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