Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/135663
Título: Effects of public health measures during the SARS-CoV-2 pandemic on the winter respiratory syncytial virus epidemic: An interrupted time series analysis
Autores/as: Reyes Domínguez, Ana Isabel 
Pavlovic Nesic, Svetlana 
Urquía Martí, Lourdes
Pérez González, María del Carmen
Reyes Suárez, Desiderio Zacarías 
García-Muñoz Rodrigo, Fermín 
Clasificación UNESCO: 32 Ciencias médicas
3201 Ciencias clínicas
3212 Salud pública
320505 Enfermedades infecciosas
320110 Pediatría
Palabras clave: Acute bronchiolitis
COVID-19
Interrupted time series analysis
Respiratory syncytial virus
SARS-CoV-2, et al.
Fecha de publicación: 2022
Publicación seriada: Paediatric and Perinatal Epidemiology 
Resumen: Background Public health measures (PHM) designed to contain the spread of COVID-19 pandemic have influenced the epidemiological characteristics of other viral infections. Its impact on acute RSV bronchiolitis in infants of ≤24 months old has not been systematically studied in our setting. Objectives To describe the monthly pattern of visits to the Paediatric Emergency Department (PED) of patients 0 to 14 years of age, the rate of patients diagnosed with RSV acute bronchiolitis per thousand inhabitants of 0 to 24 months, and the rate of them requiring hospital admission during the winter 2020–2021, in the context of local and national COVID-19 restrictions and compare them to the four previous seasons. Methods Interrupted time series analysis of patients assisted in the PED and diagnosed with or admitted for RSV acute bronchiolitis in a tertiary University Hospital from January 2016 to February 2020 (pre-intervention period) and from March 2020 to June 2021 (post-intervention period). Intervention: Preventive PHM implemented by the Spanish government weighted by the Containment and Health Index of the Oxford COVID-19 Government Response Tracker. Results The intervention was followed by an immediate reduction of the rate of visits to the PED of –19.5 (95% confidence interval [CI] –24.0, –14.9) per thousand, and the rate of diagnoses and admissions for RSV acute bronchiolitis of –44.3 (95% CI –73.8, –14.8) and –1.4 (95% CI –2.7, –0.1) per thousand, respectively, with a delayed rebound. Conclusions After the implementation of PHM to prevent the spread of SARS-CoV-2 infection, an immediate and important decline in the visits to the PED was observed, with an upward change thereafter. There was also an initial reduction in the diagnoses of and admissions by RSV acute bronchiolitis. An upward trend was observed six to nine months after the usual time of the winter RSV epidemic, coinciding with the relaxation of the preventive PHM.
URI: http://hdl.handle.net/10553/135663
ISSN: 0269-5022
DOI: 10.1111/ppe.12829
Fuente: Paediatric and Perinatal Epidemiology [ISSN 0269-5022], v. 36(3), pp. 329-336 (Mayo 2022)
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