Please use this identifier to cite or link to this item: https://accedacris.ulpgc.es/handle/10553/135660
Title: The influence of a human macronutrient-matched diet on phenotypes in old mice
Authors: Darrah, Mary A.
Longtine, Abigail G.
Greenberg, Nathan T.
Mahoney, Sophia A.
Venkatasubramanian, Ravinandan
VanDongen, Nicholas S.
Reisz, Julie A.
D’Alessandro, Angelo
Seals, Douglas R.
Bernaldo De Quirós Miranda, Yara 
Clayton, Zachary S.
UNESCO Clasification: 310512 Ordenación y conservación de la fauna silvestre
3206 Ciencias de la nutrición
Keywords: Aging
Body composition
Frailty
Rodent diets
Survival, et al
Issue Date: 2024
Journal: GeroScience 
Abstract: Preclinical rodent models are essential research tools for improving understanding of physiological aging processes in humans. However, the translatability of findings obtained leveraging rodent models to humans is limited, likely due in part to differences in macronutrient composition of the diets. Here, we investigated the impact of a 3-month diet intervention in old male C57BL/6JN mice in which the macronutrient composition was aligned with that of a midlife/older adult in the United States, compared to a traditional rodent diet, and assessed various phenotypes that are typically altered with aging. Following the diet period, mice fed the human macronutrient-matched diet had greater quadricep and subcutaneous adipose and visceral adipose tissue masses compared to animals fed a traditional mouse diet. Frailty, assessed using a clinical frailty index, was lower, while grip strength was higher in mice fed the human-matched diet. Circulating metabolite and inflammatory cytokine profiles were altered in mice fed the human-matched diet. Notably, mortality rate (assessed in animals who died or were euthanized per veterinary recommendation before the pre-determined end of study euthanasia), tended to be lower in mice fed the human-matched diet. The present study underscores the importance of diet in rodent studies of aging, as differences in macronutrient composition can affect various physiological processes in old mice that are relevant to aging research.
URI: https://accedacris.ulpgc.es/handle/10553/135660
ISSN: 2509-2715
DOI: 10.1007/s11357-024-01423-6
Source: Geroscience [ISSN 2509-2715], (Noviembre 2024)
Appears in Collections:Artículos
Show full item record

Page view(s)

27
checked on Feb 22, 2025

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.