Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/135585
Title: Lung Microbiota and Ventilator-Associated Pneumonia in the Neonatal Period
Authors: García-Muñoz Rodrigo, Fermín 
Urquía Martí, Lourdes
Siguero Onrubia, Marta 
Borges Luján, Moreyba
Galán Henríquez, Gloria
Reyes Suárez, Desiderio Zacarías 
UNESCO Clasification: 32 Ciencias médicas
320110 Pediatría
3207 Patología
320103 Microbiología clínica
Keywords: Broad-spectrum antibiotics
Endotracheal tube
Microbioma
Microbiota
Multidrug resistant pathogens, et al
Issue Date: 2024
Journal: Pathogens 
Abstract: The lung microbiota is a complex community of microorganisms that colonize the respiratory tract of individuals from, or even before, birth. Although the lungs were traditionally believed to be sterile, recent research has shown that there is a diversity of bacterial species in the respiratory system. Knowledge about the lung microbiota in newborns and its relationship with bacterial infections is of vital importance to understand the pathogenesis of respiratory diseases in neonatal patients undergoing mechanical ventilation. In this article, the current evidence on the composition of the lung microbiota in newborns will be reviewed, as well as the risks that an altered microbiota can impose on premature newborns. Although advances in neonatal intensive care units have significantly improved the survival rate of preterm infants, the diagnosis and treatment of ventilator-associated pneumonia has not progressed in recent decades. Avoiding dysbiosis caused by inappropriate use of antibiotics around birth, as well as avoiding intubation of patients or promoting early removal of endotracheal tubes, are among the most important preventive measures for ventilator-associated pneumonia. The potential benefit of probiotics and prebiotics in preventing infectious, allergic or metabolic complications in the short or long term is not clearly established and constitutes a very important field of research in perinatal medicine.
URI: http://hdl.handle.net/10553/135585
ISSN: 2076-0817
DOI: 10.3390/pathogens13030220
Source: Pathogens [eISSN 2076-0817], v. 13(3) (Marzo 2024)
Appears in Collections:Artículos
Adobe PDF (308,18 kB)
Show full item record

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.