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http://hdl.handle.net/10553/135585
Title: | Lung Microbiota and Ventilator-Associated Pneumonia in the Neonatal Period | Authors: | García-Muñoz Rodrigo, Fermín Urquía Martí, Lourdes Siguero Onrubia, Marta Borges Luján, Moreyba Galán Henríquez, Gloria Reyes Suárez, Desiderio Zacarías |
UNESCO Clasification: | 32 Ciencias médicas 320110 Pediatría 3207 Patología 320103 Microbiología clínica |
Keywords: | Broad-spectrum antibiotics Endotracheal tube Microbioma Microbiota Multidrug resistant pathogens, et al |
Issue Date: | 2024 | Journal: | Pathogens | Abstract: | The lung microbiota is a complex community of microorganisms that colonize the respiratory tract of individuals from, or even before, birth. Although the lungs were traditionally believed to be sterile, recent research has shown that there is a diversity of bacterial species in the respiratory system. Knowledge about the lung microbiota in newborns and its relationship with bacterial infections is of vital importance to understand the pathogenesis of respiratory diseases in neonatal patients undergoing mechanical ventilation. In this article, the current evidence on the composition of the lung microbiota in newborns will be reviewed, as well as the risks that an altered microbiota can impose on premature newborns. Although advances in neonatal intensive care units have significantly improved the survival rate of preterm infants, the diagnosis and treatment of ventilator-associated pneumonia has not progressed in recent decades. Avoiding dysbiosis caused by inappropriate use of antibiotics around birth, as well as avoiding intubation of patients or promoting early removal of endotracheal tubes, are among the most important preventive measures for ventilator-associated pneumonia. The potential benefit of probiotics and prebiotics in preventing infectious, allergic or metabolic complications in the short or long term is not clearly established and constitutes a very important field of research in perinatal medicine. | URI: | http://hdl.handle.net/10553/135585 | ISSN: | 2076-0817 | DOI: | 10.3390/pathogens13030220 | Source: | Pathogens [eISSN 2076-0817], v. 13(3) (Marzo 2024) |
Appears in Collections: | Artículos |
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