Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/135032
Title: Pregnancy outcomes with the pregestational use of Minimed 780G compared to Minimed 640G: findings from a multicenter cohort study
Authors: Perea, Veronica
Quiros, Carmen
Herrera-Arranz, Maria Teresa
Azriel-Mira, Sharona
Wägner, Anna Maria Claudia 
Beato-Vibora, Pilar
Soldevila, Berta
Barquiel, Beatriz
Pardo, Rosa Marquez
Diaz-Soto, Gonzalo
Picon, Maria Jose
Colomo, Natalia
Amigo, Judit
Climent, Elisenda
Duran-Martinez, Maria
Corcoy, Rosa
Codina, Mercedes
Cuesta, Martin
Guedes, Begona Vega
Vinagre, Irene
UNESCO Clasification: 32 Ciencias médicas
3314 Tecnología médica
Keywords: Severe Hypoglycemia
Glycemic Control
Type-1
Women
Management, et al
Issue Date: 2024
Journal: Acta Diabetologica 
Abstract: AimTo compare glycemic control and maternal-fetal outcomes of women with type 1 diabetes (T1D) using Minimed (TM) 780G (MM780G) with those women using Minimed (TM) 640G (MM640G) since before pregnancy.MethodsMulticenter prospective cohort study of pregnant women with T1D in Spain. We evaluated HbA1c, time spent within (TIRp), below (TBRp) and above (TARp) the pregnancy-specific glucose range 3.5-7.8 mmol/L (63-140 mg/dL) and glucose variability (CV).ResultsSixty-nine women were included (MM780G n = 40). At baseline, MM640G users had higher rates of severe hypoglycemia before pregnancy, without other between-group differences. The MM780G group had higher TIRp and lower TARp, TBRp and CV, but similar HbA1c in the first trimester of gestation. TBRp and CV remained significantly higher in the MM640G group throughout pregnancy. Higher HbA1c was observed in the MM780G group compared to the MM640G (6.28 +/- 0.53% [45.1 +/- 5.8 mmol/mol] vs. 5.97 +/- 0.62 [41.8 +/- 6.8], p = 0.003) in the second trimester. There were no differences in the mean change in HbA1c from the first to the third trimester of gestation between groups. MM780G users were more likely to have large-for-gestational-age infants (ORadjusted 4.85, 95% CI 1.46-16.13, p = 0.010), macrosomia (ORadjusted 12.17, 95% CI 1.49-99.72, p = 0.020) and cesarean section (ORadjusted 4.19, 95% CI 1.34-13.11, p = 0.014) than the MM640G group.ConclusionsPregestational use of MM780G led to an initial improvement in TIRp, but this was not sustained in the second and third trimesters, with a 4-fold increased risk of delivering a LGA infant and undergoing cesarean section compared to MM640G users.
URI: http://hdl.handle.net/10553/135032
ISSN: 0940-5429
DOI: 10.1007/s00592-024-02430-x
Source: Acta Diabetologica[ISSN 0940-5429], (2024)
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