Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/133141
Title: The bottlenose dolphin (Tursiops truncatus): A novel model for studying healthy arterial aging
Authors: Bernaldo De Quirós Miranda, Yara 
Mahoney, Sophia A.
VanDongen, Nicholas S.
Greenberg, Nathan T.
Venkatasubramanian, Ravinandan
Saavedra Santana, Pedro 
Bossart, Gregory
Brunt, Vienna E.
Clayton, Zachary S.
Fernández Rodríguez, Antonio Jesús 
Seals, Douglas R.
UNESCO Clasification: 240119 Zoología marina
240113 Fisiología animal
Keywords: advancing age
cardiovascular disease
cetaceans; diving
endothelial function
Issue Date: 2023
Journal: American Journal of Physiology - Heart and Circulatory Physiology 
Abstract: Endothelial function declines with aging and independently predicts future cardiovascular disease (CVD) events. Diving also impairs endothelial function in humans. Yet, dolphins, being long-lived mammals adapted to diving, undergo repetitive cycles of tissue hypoxia-reoxygenation and disturbed shear stress without manifesting any apparent detrimental effects, as CVD is essentially nonexistent in these animals. Thus, dolphins may be a unique model of healthy arterial aging and may provide insights into strategies for clinical medicine. Emerging evidence shows that the circulating milieu (bioactive factors in the blood) is at least partially responsible for transducing reductions in age-related endothelial function. To assess if dolphins have preserved endothelial function with aging due to a protected circulating milieu, we tested if the serum (pool of the circulating milieu) of bottlenose dolphins (Tursiops truncatus) induces the same arterial aging phenotype as the serum of age-equivalent humans. We incubated conduit arteries from young and old mice with dolphin and human serum and measured endothelial function ex vivo via endothelium-dependent dilation to acetylcholine. While young arteries incubated with serum from mid-life/older adult human serum had lower endothelial function, those incubated with dolphin serum consistently maintained high endothelial function regardless the age of the donor. Thus, studying the arterial health of dolphins could lead to potential novel therapeutic strategies to improve age-related endothelial dysfunction in humans.
URI: http://hdl.handle.net/10553/133141
ISSN: 0363-6135
DOI: 10.1152/ajpheart.00464.2024
Source: American Journal of Physiology - Heart and Circulatory Physiology[ISSN0363-6135], v.327 (3), Septiembre 2024
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