Please use this identifier to cite or link to this item:
Title: Analysis of Protection and Immune Response against Teladorsagia circumcincta in Goats Immunised with Thiol-Binding Proteins from Adult Worms
Authors: Ortega, Leire
Quesada, Jessica
Ruiz Reyes, Antonio 
Conde De Felipe, Magnolia María 
Ferrer Quintana, Otilia Rosa 
Muñoz Ojeda, María Del Carmen 
Molina Ferrer, José Adrián 
Rodríguez Guisado, Francisco 
Molina Caballero, José Manuel 
UNESCO Clasification: 240112 Parasitología animal
310907 Patología
230227 Proteínas
Keywords: goat
immune response
Telacorsagia circumcincta
thiol-binding proteins
Issue Date: 2024
Journal: Vaccines 
Abstract: In view of the increasing occurrence of anthelmintic-resistant strains of gastrointestinal nematodes in ruminants, various alternative control strategies have been investigated, such as those based on the induction of protective immune responses by immunisation with parasite antigens. In this study, the protective activity of somatic antigens from adult worms of Teladorsagia circumcincta purified by affinity chromatography on thiol-sepharose was analysed in goats. After challenge, the enriched products induced a slight reduction in the cumulative faecal egg counts (21%) and in the number of worms (23.3%), with a greater effect on female worms, which also showed a reduction in parameters related to their fertility. These parasitological findings were associated with a Th2 immune response, with a prominent local humoral response and an eosinophilic infiltrate in the gastric mucosa (negatively associated with the fertility of female worms and the number of worms, respectively), as well as an infiltration of MCHII+, CD4+, IgG+ and IgA+ cells. However, several analyses showed an increase in CD8+ cells in the mucosa, as well as IL-2 expression in the gastric lymph nodes, which may have been associated with inhibition of protective responses or with the development of mixed Th1/Th2 responses, a finding that should be analysed in future studies.
ISSN: 2076-393X
DOI: 10.3390/vaccines12040437
Source: Vaccines [ISSN2076-393X], v.12(4)
Appears in Collections:Artículos
Adobe PDF (2,26 MB)
Show full item record

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.