Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/130180
Título: Analysis of Protection and Immune Response against Teladorsagia circumcincta in Goats Immunised with Thiol-Binding Proteins from Adult Worms
Autores/as: Ortega, Leire
Quesada, Jessica
Ruiz Reyes, Antonio 
Conde De Felipe, Magnolia María 
Ferrer Quintana, Otilia Rosa 
Muñoz Ojeda, María Del Carmen 
Molina Ferrer, José Adrián 
Rodríguez Guisado, Francisco 
Molina Caballero, José Manuel 
Clasificación UNESCO: 240112 Parasitología animal
310907 Patología
230227 Proteínas
Palabras clave: goat
immune response
immunisation
Telacorsagia circumcincta
thiol-binding proteins
Fecha de publicación: 2024
Publicación seriada: Vaccines 
Resumen: In view of the increasing occurrence of anthelmintic-resistant strains of gastrointestinal nematodes in ruminants, various alternative control strategies have been investigated, such as those based on the induction of protective immune responses by immunisation with parasite antigens. In this study, the protective activity of somatic antigens from adult worms of Teladorsagia circumcincta purified by affinity chromatography on thiol-sepharose was analysed in goats. After challenge, the enriched products induced a slight reduction in the cumulative faecal egg counts (21%) and in the number of worms (23.3%), with a greater effect on female worms, which also showed a reduction in parameters related to their fertility. These parasitological findings were associated with a Th2 immune response, with a prominent local humoral response and an eosinophilic infiltrate in the gastric mucosa (negatively associated with the fertility of female worms and the number of worms, respectively), as well as an infiltration of MCHII+, CD4+, IgG+ and IgA+ cells. However, several analyses showed an increase in CD8+ cells in the mucosa, as well as IL-2 expression in the gastric lymph nodes, which may have been associated with inhibition of protective responses or with the development of mixed Th1/Th2 responses, a finding that should be analysed in future studies.
URI: http://hdl.handle.net/10553/130180
ISSN: 2076-393X
DOI: 10.3390/vaccines12040437
Fuente: Vaccines [ISSN2076-393X], v.12(4)
Colección:Artículos
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