Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/130173
Título: Cocktail effects of tire wear particles leachates on diverse biological models: A multilevel analysis
Autores/as: Le Du-Carrée, Jessy Medhy Manu 
Palacios, Clara Kempkens
Rotander, Anna
Larsson, Maria
Alijagic, Andi
Kotlyar, Oleksandr
Engwall, Magnus
Sjöberg, Viktor
Keiter, Steffen H.
Almeda, Rodrigo 
Clasificación UNESCO: 330811 Control de la contaminación del agua
331210 Plásticos
251001 Oceanografía biológica
Palabras clave: Cell painting
Endocrine disruption
In vivo toxicity testing
Leachate cocktail toxicity
Tire wear particles
Fecha de publicación: 2024
Proyectos: Impacto de Los Aditivos Lixiviados de Los Microplásticos en El Plancton 
Publicación seriada: Journal of Hazardous Materials 
Resumen: Tire wear particles (TWP) stand out as a major contributor to microplastic pollution, yet their environmental impact remains inadequately understood. This study delves into the cocktail effects of TWP leachates, employing molecular, cellular, and organismal assessments on diverse biological models. Extracted in artificial seawater and analyzed for metals and organic compounds, TWP leachates revealed the presence of polyaromatic hydrocarbons and 4-tert-octylphenol. Exposure to TWP leachates (1.5 to 1000 mg peq L−1) inhibited algae growth and induced zebrafish embryotoxicity, pigment alterations, and behavioral changes. Cell painting uncovered pro-apoptotic changes, while mechanism-specific gene-reporter assays highlighted endocrine-disrupting potential, particularly antiandrogenic effects. Although heavy metals like zinc have been suggested as major players in TWP leachate toxicity, this study emphasizes water-leachable organic compounds as the primary causative agents of observed acute toxicity. The findings underscore the need to reduce TWP pollution in aquatic systems and enhance regulations governing highly toxic tire additives.
URI: http://hdl.handle.net/10553/130173
ISSN: 0304-3894
DOI: 10.1016/j.jhazmat.2024.134401
Fuente: Journal of Hazardous Materials [ISSN 0304-3894], v. 471, (Junio 2024)
Colección:Artículos
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