Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/130120
Title: A multi-criteria decision analysis on the value of nintedanib for interstitial lung diseases
Authors: Zozaya González, María Neboa 
Arrizubieta Basterrechea, Maria Iciar
Bollo, Elena
Castellví, Iván
Espín, Jaime
Ortego, Norberto
Poveda-Andrés, José Luis
Rodríguez Portal, José Antonio
Rivero, Agustín
Marcos-Rodríguez, José Antonio
Verde, Luis
UNESCO Clasification: 53 Ciencias económicas
531207 Sanidad
Keywords: Interstitial lung diseases
Systemic sclerosis
Pulmonary fibrosis
Multi-criteria decision analysis
Issue Date: 2022
Journal: International Journal of Technology Assessment in Health Care 
Abstract: Objectives: Our aim was to assess the value of nintedanib for non-idiopathic progressive fibrosing interstitial lung disease (non-IPF PF-ILD) and systemic sclerosis-associated ILD (SSc-ILD) in the Spanish context, using a multi-criteria decision analysis (MCDA). Methods: Following an adaptation of the Evidence and Value: Impact on DEcision Making (EVIDEM) MCDA methodology, the estimated value of nintedanib was obtained by means of an additive linear model that combined individual weights (100-points distribution) of criteria with the individual scoring of nintedanib in each criterion for every indication, assigned by a multidisciplinary committee of twelve clinicians, patients, pharmacists, and decision-makers. To assess the reproducibility, an alternative weighting method was applied, as well as a re-test of weights and scores at a different moment of time. Results: The experts committee recognized nintedanib as an intervention with a positive value contribution in comparison to placebo for the treatment of non-IPF PF-ILD (0.50 0.16, on a scale from 1 to 1) and SSc-ILD (0.40 0.12), diseases which were considered as very severe and with high unmet needs. The drug was perceived as a treatment that provides an added therapeutic benefit for patients (0.06–0.07), given its proven clinical efficacy (0.05–0.06), slight improvements in patient-reported outcomes (0.01–0.02), and similar safety profile than placebo ( 0.04–0.00), which will likely be positioned as a recommended therapy in the next clinical practice guidelines updates. Conclusions: Under this increasingly used methodology, nintedanib has shown to provide a positive value estimate for non-IPF PF-ILD and SSc-ILD when compared to placebo in Spain.
URI: http://hdl.handle.net/10553/130120
ISSN: 0266-4623
DOI: 10.1017/S0266462322000459
Source: International Journal of Technology Assessment in Health Care [ISSN 0266-4623], v. 38, n. 1, p. 1-10, (Julio 2022)
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