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Title: The gut microbiome as a modulator of arterial function and age-related arterial dysfunction
Authors: Longtine, Abigail G.
Greenberg, Nathan T.
Bernaldo De Quirós Miranda, Yara 
Brunt, Vienna E.
UNESCO Clasification: 310905 Microbiología
240113 Fisiología animal
Keywords: arterial stiffness
cardiovascular health
endothelial function
gut-derived metabolites
gut-targeted thera
Issue Date: 2024
Project: Arterial Aging
Journal: American Journal of Physiology - Heart and Circulatory Physiology 
Abstract: The arterial system is integral to the proper function of all other organs and tissues. Arterial function is impaired with aging, and arterial dysfunction contributes to the development of numerous age-related diseases, including cardiovascular diseases. The gut microbiome has emerged as an important regulator of both normal host physiological function and impairments in function with aging. The purpose of this review is to summarize more recently published literature demonstrating the role of the gut microbiome in supporting normal arterial development and function and in modulating arterial dysfunction with aging in the absence of overt disease. The gut microbiome can be altered due to a variety of exposures, including physiological aging processes. We explore mechanisms by which the gut microbiome may contribute to age-related arterial dysfunction, with a focus on changes in various gut microbiome-related compounds in circulation. In addition, we discuss how modulating circulating levels of these compounds may be a viable therapeutic approach for improving artery function with aging. Finally, we identify and discuss various experimental considerations and research gaps/areas of future research.
ISSN: 0363-6135
DOI: 10.1152/ajpheart.00764.2023
Source: American Journal of Physiology - Heart and Circulatory Physiology [ISSN 0363-6135], v.326(4)
Appears in Collections:Artículos
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