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Title: The cardiovascular event risk associated with Tyrosine Kinase Inhibitors and the lipid rrofile in patients with chronic myeloid leukemia
Authors: Saez Perdomo, María Nieves
Stuckey, Ruth
González-Pérez, Elena
Sánchez-Sosa, Santiago
Estupiñan-Cabrera, Paula
Lakhwani Lakhwani, Sunil
González San Miguel, José David
Hernanz Soler, Nuria
Gordillo, Marina
González Brito, Gloria
Tapia-Torres, María
Ruano, Ana
Segura Díaz, Adrian 
Luzardo, Hugo
Bilbao Sieyro, Cristina 
Gómez Casares, María Teresa 
UNESCO Clasification: 32 Ciencias médicas
320708 Hematología
320713 Oncología
Keywords: Adverse Event
Chronic Myeloid Leukemia
Lipid Metabolism, et al
Issue Date: 2024
Journal: Hematology Reports 
Abstract: Background: Second- and third-generation tyrosine kinase inhibitors (TKIs) are now available to treat chronic-phase chronic myeloid leukemia (CP-CML) in the first and second line. However, vascular adverse events (VAEs) have been reported for patients with CML treated with some TKIs. Methods: We retrospectively evaluated the cumulative incidence (CI) and cardiovascular risk for 210 patients included in the Canarian Registry of CML. Result: With a mean follow up of 6 years, 19/210 (9.1%) patients developed VAEs, all of whom presented at least one cardiovascular risk factor at diagnosis. The mean time to VAE presentation was 54 months from the start of TKI treatment. We found a statistically significant difference between the CI for nilotinib-naïve vs. nilotinib-treated patients (p = 0.005), between dasatinib-naïve and dasatinib-treated patients (p = 0.039), and for patients who received three lines of treatment with first-line imatinib vs. first-line imatinib (p < 0.001). From the multivariable logistic regression analyses, the Framingham risk score (FRS) and patients with three lines of TKI with first-line imatinib were the only variables with statistically significant hazard ratios for VAE development. Significant increases in HDL-C and total cholesterol may also be predictive for VAE. Conclusions: In conclusion, it is important to estimate the cardiovascular risk at the diagnosis of CML as it can help determine whether a patient is likely to develop a VAE during TKI treatment.
ISSN: 2038-8322
DOI: 10.3390/hematolrep16010015
Source: Hematology Reports [ISSN 2038-8322], v. 16 (1), p. 140-150, (Marzo 2024).
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