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http://hdl.handle.net/10553/128824
Título: | Prevalence, antimicrobial resistance, and genetic lineages of nasal Staphylococcus aureus among medical students at a Spanish University: detection of the MSSA-CC398-IEC-type-C subclade | Autores/as: | Rosales González, Nerea C. González Martín, Margarita Rosa Abdullahi, Idris Nasir Tejedor Junco, María Teresa Latorre-Fernández, Javier Torres, Carmen |
Clasificación UNESCO: | 32 Ciencias médicas 320104 Patología clínica 320505 Enfermedades infecciosas |
Palabras clave: | Antimicrobial resistance Medical students MSSA-CC398 Nasal carriage Nosocomial MRSA |
Fecha de publicación: | 2023 | Publicación seriada: | Research in Microbiology | Resumen: | Medical students could be a potential source of Staphylococcus aureus transmission to patients. This cross-sectional study involved samples collected from both nasal nostrils. Samples were processed for S. aureus recovery; the antimicrobial resistance (AMR) phenotype was determined by disc diffusion assays and the spa types and AMR genotypes by PCR/sequencing. A structured questionnaire was administered to students to collate data related to potential risk factors of nasal colonization. Ninety-eight students were included, 50 % were colonized by S. aureus and 12.2 % by MRSA. The mecA gene was detected in all MRSA isolates. The MSSA-CC398-IEC-type C lineage was found among 16.3 % of nasal carriers, of which t571 was the predominant spa-type. MRSA isolates were ascribed to spa types t2226 (CC5, 12 isolates) and t3444 (new spa type, 1 isolate). All MRSA were multi-drug resistant and MSSA were predominantly resistant to erythromycin-clindamycin (inducible-type, mediated by ermT gene). High rates of S. aureus and MRSA nasal carriages were observed in this study. The predominance of the CC398 lineage among MSSA (emergent invasive lineage) represent a relevant finding of public health concern. The role of medical students as potential source of MRSA and MSSA-CC398 transmissions in hospital and community needs to be elucidated in detail. | URI: | http://hdl.handle.net/10553/128824 | ISSN: | 0923-2508 | DOI: | 10.1016/j.resmic.2023.104176 | Fuente: | Research in Microbiology [ISSN 0923-2508], 104176, (Diciembre 2023) |
Colección: | Artículos |
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