Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/128038
Título: Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM)
Autores/as: Sari-Ak, D
Torres Gómez, Álvaro 
Yazicioglu, YF
Christofides, A
Patsoukis, N
Lafuente, EM
Boussiotis, VA
Clasificación UNESCO: 32 Ciencias médicas
2412 Inmunología
Palabras clave: Leukocytes
Integrins
Rap1
RIAM
Adhesion, et al.
Fecha de publicación: 2022
Publicación seriada: Biomedical Journal 
Resumen: Leukocytes, the leading players of immune system, are involved in innate and adaptive immune responses. Leukocyte adhesion to endothelial cells during transmigration or to antigen presenting cells during T cell activation, requires integrin activation through a process termed inside-out integrin signaling. In hematopoietic cells, Rap1 and its downstream effector RIAM (Rap1-interacting adaptor molecule) form a cornerstone for inside-out integrin activation. The Rap1/RIAM pathway is involved in signal integration for activation, actin remodeling and cytoskeletal reorganization in T cells, as well as in myeloid cell differentiation and function. RIAM is instrumental for phagocytosis, a process requiring particle recognition, cytoskeletal remodeling and membrane protrusion for engulfment and digestion. In the present review, we discuss the structural and molecular properties of RIAM and the recent discoveries regarding the functional role of the Rap1/RIAM module in hematopoietic cells.
URI: http://hdl.handle.net/10553/128038
ISSN: 2319-4170
DOI: 10.1016/j.bj.2021.09.005
Fuente: Biomedical Journal [ISSN 2319-4170], v. 45, n. 2, p. 289-298
Colección:Artículos
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