Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/128031
Título: Phagocytic Integrins: Activation and Signaling
Autores/as: Torres Gómez, Álvaro 
Cabañas, C
Lafuente, EM
Clasificación UNESCO: 32 Ciencias médicas
Palabras clave: Phagocytosis
Integrins
Signaling
CR3
Mac-1, et al.
Fecha de publicación: 2020
Publicación seriada: Frontiers in Immunology 
Resumen: Phagocytic integrins are endowed with the ability to engulf and dispose of particles of different natures. Evolutionarily conserved from worms to humans, they are involved in pathogen elimination and apoptotic and tumoral cell clearance. Research in the field of integrin-mediated phagocytosis has shed light on the molecular events controlling integrin activation and their effector functions. However, there are still some aspects of the regulation of the phagocytic process that need to be clarified. Here, we have revised the molecular events controlling phagocytic integrin activation and the downstream signaling driving particle engulfment, and we have focused particularly on αMβ2/CR3, αXβ2/CR4, and a brief mention of αVβ5/αVβ3integrins.
URI: http://hdl.handle.net/10553/128031
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.00738
Fuente: Frontiers in Immunology [ISSN 1664-3224], v. 11
Colección:Artículos
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