RIAM (Rap1-Interactive Adaptor Molecule)

Abstract

RIAM was identified in a search of new effector molecules of the small guanosine triphosphatase (GTPase) Rap1, using the yeast two-hybrid system screen. Due to its interaction with Rap1, the newly identified Rap1-interacting effector was named RIAM (Rap1-interacting adaptor molecule) (Lafuente et al. 2004). Before its identification as a Rap1-interacting molecule, RIAM was found as a binding partner of the amyloid beta (A4) precursor protein-binding, family B, member 1 (APBB1) – also known as neural Fe65 protein – and was termed amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein (APBB1IP) (Ermekova et al. 1997). In an independent study, RIAM was identified as a protein whose expression was induced in response to all-transretinoic acid...