Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/128021
Title: The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression
Authors: Patsoukis, N
Bardhan, K
Weaver, JD
Sari, D
Torres Gómez, Álvaro 
Li, LQ
Strauss, L
Lafuente, EM
Boussiotis, VA
UNESCO Clasification: 32 Ciencias médicas
2412 Inmunología
Issue Date: 2017
Journal: Science Signaling 
Abstract: Lymphocyte activation requires adhesion to antigen-presenting cells. This is a critical event linking innate and adaptive immunity. Lymphocyte adhesion is accomplished through LFA-1, which must be activated by a process referred to as inside-out integrin signaling.Among the fewsignaling molecules that have been implicated in inside-out integrin activation in hematopoietic cells are the small guanosine triphosphatase (GTPase) Rap1 and its downstream effector Rap1-interacting molecule (RIAM), a multidomain protein that defined the Mig10-RIAM-lamellipodin (MRL) class of adaptor molecules. Through its various domains, RIAM is a critical node of signal integration for activation of T cells, recruits monomeric and polymerized actin to drive actin remodeling and cytoskeletal reorganization, and promotes inside-out integrin signaling in T cells. As a regulator of inside-out integrin activation, RIAMaffectsmultiple functions of innate and adaptive immunity. The effects of RIAM on cytoskeletal reorganization and integrin activation have implications in cell migration and trafficking of cancer cells. Weprovide an overviewof the structure and interactions of RIAM, and we discuss the implications of RIAM functions in innate and adaptive immunity and cancer.
URI: http://hdl.handle.net/10553/128021
ISSN: 1945-0877
DOI: 10.1126/scisignal.aam8298
Source: Science Signaling [ISSN 1945-0877], v. 10, n. 493
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