Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/127997
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dc.contributor.authorDomínguez Sosa, Maria Sandraen_US
dc.contributor.authorCabrera Ramírez, María Soledaden_US
dc.contributor.authorMarrero Ramos, Miriam Del Carmenen_US
dc.contributor.authorDávila Quintana, Carmen Deliaen_US
dc.contributor.authorCabrera López, Carlosen_US
dc.contributor.authorCarrillo Díaz, Teresaen_US
dc.contributor.authorBenítez Del Rosario, Jesúsen_US
dc.date.accessioned2023-12-19T14:28:25Z-
dc.date.available2023-12-19T14:28:25Z-
dc.date.issued2023en_US
dc.identifier.issn2227-9059en_US
dc.identifier.urihttp://hdl.handle.net/10553/127997-
dc.description.abstractThe aim of this study was to evaluate the efficacy of mepolizumab in patients affected by chronic rhinosinusitis with nasal polyps (CRSwNP) in real-life. A single-center retrospective observational study was conducted on severe CRSwNP patients treated with mepolizumab. Nasal endoscopic polyp score (NPS), visual analogue scale (VAS) symptom score, sinonasal outcome test (SNOT-22), asthma control test (ACT) score, fractional exhaled nitric oxide (FeNO), eosinophils blood cells and prednisone intake were assessed at baseline and after 6 months. A total of 55 patients were included; 49 patients (89%) presented with asthma; aspirin exacerbated respiratory disease (AERD) in 28 patients (51%). A statistically significant decrease in the SNOT-22 score was observed (median difference −63; 95% CI: −68; −58; p < 0.001) with median t0 76 and IQR (61;90) to t6 10 (5;15). A reduction in NPS, median t0 NPS 4; (IQR:4;6), median t6 NPS 1; (IQR:0;1) p < 0.001, was greater in patients with AERD. The median baseline VAS score was 6 (IQR:6;7) and the differences between t0 and t6 were statistically significant p < 0.001. Significant changes in blood eosinophils cells, median t0 500 cell/mcl (IQR:340;830), median t6 97 cell/mcl (IQR:60;160) p < 0.001, were greater in patients with AERD. Mepolizumab treatment effects have been demonstrated with significantly reduced symptoms, polyp scores, blood eosinophils and systemic corticosteroid use, resulting in an increased health-related quality of life in patients with severe CRSwNP, regardless of the presence or absence of asthma or AERD.en_US
dc.languageengen_US
dc.relation.ispartofBiomedicinesen_US
dc.sourceBiomedicines [2227-9059], v. 11(2):485 (Febrero 2023)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3209 Farmacologíaen_US
dc.subject320701 Alergiasen_US
dc.subject.otherChronic rhinosinusitisen_US
dc.subject.otherNasal polypsen_US
dc.subject.otherMepolizumaben_US
dc.subject.otherAspirin exacerbated respiratory diseaseen_US
dc.subject.otherSNOT-22en_US
dc.subject.otherNasal polyp scoreen_US
dc.titleReal-Life Effectiveness of Mepolizumab in Refractory Chronic Rhinosinusitis with Nasal Polypsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/biomedicines11020485en_US
dc.identifier.scopus2-s2.0-85148882192-
dc.identifier.isiWOS:000938379700001-
dc.contributor.orcid0000-0001-9445-4537-
dc.contributor.orcid0000-0001-6164-107X-
dc.contributor.orcid0000-0002-6679-0557-
dc.contributor.orcid0000-0002-4608-1040-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.identifier.issue2-
dc.relation.volume11en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages15en_US
dc.utils.revisionen_US
dc.date.coverdateFebrero 2023en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr0,962
dc.description.jcr3,9
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.esciESCI
dc.description.miaricds10,4
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptDepartamento de Métodos Cuantitativos en Economía y Gestión-
crisitem.author.deptGIR IUIBS: Patología y Tecnología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR SIANI: Ingeniería biomédica aplicada a estimulación neural y sensorial-
crisitem.author.deptIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-4608-1040-
crisitem.author.orcid0000-0002-3047-8908-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.fullNameDomínguez Sosa, Maria Sandra-
crisitem.author.fullNameMarrero Ramos, Miriam Del Carmen-
crisitem.author.fullNameDávila Quintana, Carmen Delia-
crisitem.author.fullNameCarrillo Díaz, Teresa-
crisitem.author.fullNameBenítez Del Rosario, Jesús-
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